新生儿窒息患儿血清肿瘤坏死因子水平的临床研究

A Clinical Study of the Levels of Tumor Necrosis Factor-α in Neonates with Asphyxia

目的：观察窒息对新生儿血清肿瘤坏死因子－α（ＴＮＦ－α）值的影响。方法：用放射免疫法测定５５例窒息新生儿血清ＴＮＦ－α的变化，同时测定１５例正常足月新生儿脐动脉血作对照。结果：窒息新生儿组血清ＴＮＦ－α明显高于对照组，并且血清ＴＮＦ－α水平与Ａｐｇａｒ评分密切相关，重度窒息组比轻度窒息组血清ＴＮＦ－α明显增高。结论：ＴＮＦ－α在新生儿窒息的发病机制中起一定作用。对重度窒息患儿及早使用抗ＴＮＦ－α单克隆抗体，可减轻脑水肿，阻断继发性脑损伤。

Objective:To examine the plasma livel of tumor necrosis factor-α(TNF-α)in neonates with asphyxia.Method:The plasma level of TNF-α was determinated with radioimmunoassay in 55 neonates with asphyxia and in 15 healthy neonates.Result:The plasma level of TNF-α in neonates with asphyxia was significantly higher than that in control,and it was obviously related to both Apgar score and severity of asphyxia.Conclusion:TNF-α plays a role in the pathogenesis of asphyxia.In treatment of severe asphyxia,the monoclonal antibody against TNF-α should be used as early as possible in order to reduce the brain edema and block the secondary brain injury.