苯妥英钠血浓度与神经毒性关系的研究

STUDY ON THE RELATION BETWEEN CONCENTRATION OF PHENYTORINUM NATRICUM IN SERUM AND NEUROTOXICITY OF IT

目的观察苯妥英钠血浓度与神经毒性的关系。方法用ＨＰＬＣ法测定苯妥英钠血浓度。结果出现苯妥英钠神经毒性反应者的血浓度为１５～５１μｇ／ｍｌ，平均为３０±８．２μｇ／ｍｌ。诱导出眼球震颤，共济失调及精神症状的血浓度分别为２２±４．１μｇ／ｍｌ，３０±８．２μｇ／ｍｌ及４７±４．０μｇ／ｍｌ。结论四分之一患者在相对安全的有效血浓度范围内出现药物不良反应。调整苯妥英钠剂量应据其临床发作情况，药物不良及血浓度综合分析。

Objective To study the relation between concentration of phenytorinum natricum (CPN) in serum and neurotoxicity of the drug. Methods CPN in serum was measured by using HPLC method. Results The neurotoxicity of the drug appearcd when the CPN in the serum were 15～51μg/ml caverage:30±8.2μg/ml). The nystagmus, ataxia and mental symptoms were induced when the CPN in serum were 22±4.1μg/ml, 30±8.2μg/ml and 47±4.0μg/ml, respectively. The bad drug reaction appeared among 25% patients when the CPN in serum was in the relatively safe limits. Conclusion The dosage of the drug must be regulated according to the general analysis of clinical state, appearance of bad drug reaction and CPN in serum