CTLA-4基因49A／G多态性与Graves病复发相关

CTLA-4 gene 49 A/G polymorphism is associated with relapse of Graves＇ disease

采用PCR-RFLP对120例Graves病（GD）复发患者（停药3年内复发85例，3年后复发35例），66例GD初发患者和100例健康对照的细胞毒性T淋巴细胞相关抗原4（CTLA-4）基因A／G多态性进行检测。结果提示，CTLA-4第1外显子49位点A／G多态性在中国北方汉族人不仅与GD发生相关，而且影响GD停药后缓解的持续时间，与早期复发相关。

The A/G polymorphism of cytotoxic T lymphocyte associated antiger 4 （CTLA-4） was determined by PCR-RFLP in 120 patients with recurrent Graves＇ disease （GD）, including 85 cases with early relapses within 3 years and 35 cases with relapses more than 3 years after withdrawal of antithyroid medication. 66 initial GD patients and 100 healthy controls were included in the present study. The results suggest that A/G polymorphism of CTLA-4 was associated not only with GD, but also with early relapes after withdrawal of antithyroid medication.