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硒在桥本甲状腺炎中的作用 被引量:13

Effect of selenium on the Hashimoto thyroiditis
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摘要 115例确诊为桥本甲状腺炎的患者,其中59例予以亚硒酸钠和左旋甲状腺素(L-T4)治疗,其余患者仍以L-T4治疗,随访3个月后,结果显示硒治疗组中56%患者甲状腺过氧化物酶抗体降低,61%患者甲状腺球蛋白抗体降低,此结果优于单纯L-T4治疗组。 A total of 115 patients with Hoshimoto thyroiditis were classified under 2 groups: one group being treated with selenium and L-throxine (L-T4) and other group with L-T4 alone. All patients were followed up for 3 months. In the selenium treated group thyroid peroxidase antibody level was decreased in 33 patients (56%) and thyroglobulin antibody level was decreased in 36 patients ( 61% ), which seems to be superior to those in solely L-T4 treated cases.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2008年第2期194-195,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 桥本甲状腺炎 甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 Selenium Hashimoto thyroiditis Thyroid peroxidase antibodies Thyroglobulin antibodies
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参考文献5

  • 1John RA, Roderick C, Mckenzie, et al. Selenium in the immune sys- tem. J Nutr, 2003,133:1457S-1459S.
  • 2Geoffrey JB, John RA. Selenium and endocrine systems. J Endocrinol, 2005,184:455-465.
  • 3刘莉,平智广,朱本章.自身免疫性甲状腺病患者血清硒水平[J].中华内分泌代谢杂志,2005,21(6):537-538. 被引量:24
  • 4Leonidas HD, Emilla M, Demetrios AK. Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis. Eur Endo- crinol, 2003,148:389-393.
  • 5Roland G, Barbara CH, Gasnier J, et al. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidese antibodies concentrations. J Clin Endocrinol Metab, 2002,87:1687-1691.

二级参考文献5

  • 1Kucharzewski M, Braziewicz J, Majewska U, et al. Concentration of selenium in the whole blood and the thyroid tissue of patients with various thyroid diseases. Biol Trace Elem Res, 2002,88:25-30.
  • 2Ghose A, Fleming J, Harrison PR. Selenium and signal transduction: roads to cell death and anti-tumour activity. Biofactors, 2001,14: 127-133.
  • 3Gartner R, Gasnier BC. Selenium in the treatment of autoimmune thyroiditis. Biofactors, 2003,19 : 165-170.
  • 4刘莉,朱本章.微量元素硒与甲状腺[J].国外医学(医学地理分册),2003,24(3):122-124. 被引量:3
  • 5刘莉,朱本章.硒缺乏与甲状腺疾病[J].国外医学(内分泌学分册),2003,23(6):386-388. 被引量:9

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