血清组织蛋白酶S、胱抑素C水平与冠状动脉粥样硬化病变严重程度相关性的研究——附107例报告

Correlation between serum levels of cathepsin S and cystatin C and the severity of atherosclerostic lesions of coronary arteries

目的:探讨冠状动脉粥样硬化性心脏病(冠心病)患者血清组织蛋白酶S(cathepsinS,CatS)及胱抑素C水平与冠状动脉病变程度的关系。方法:对155例疑诊心绞痛患者进行冠状动脉造影(coronary angiography,CAG),根据CAG结果分为冠心病组(107例)及对照组(48例),测定所有入选者的空腹血清CatS、胱抑素C水平,采用Gensini积分对冠状动脉病变程度进行评价并分析它们之间的关系。结果:冠心病组血清CatS、胱抑素C水平较对照组高(P(0.01),前者上升幅度更大,血清CatS水平与Gensini积分呈正相关(r=0.69,P(0.01),Logistic回归分析剔除年龄、性别、收缩压、血清总胆固醇等因素后,此相关性仍存在(r=0.71,P(0.01)。结论:冠心病患者的血清CatS、胱抑素C的水平增高,且CatS与冠状动脉粥样硬化病变程度密切相关,说明CatS及胱抑素C可能参与细胞外基质重塑的过程。

Objective： To investigate the correlation between serum levels of cathepsin S and cystatin C and the severity of atherosclerostic lesions of coronary arteries. Methods ： 155 patients were undertaken coronary angiography and divided into the coronary artery disease group （ n = 107） and the control group （ n = 48 ） according to the result. Fasting total serum concentrations of cathepsin S and cystatin C were measured and the severity of lesions of coronary arteries were assessed and analyzed by Gensini score in all patients. Results： In contrast with the control group, serum levels of cathepsin S and cystatin C in coronary artery disease group increased significantly and cathepsin S was demonstrated positively correlative with Gensini score （ r = 0.69, P 〈 0.01 ）. After being corrected age, sex, blood pressure and blood lipid factors by Logistic analysis, this relationship still existed （r = 0. 71, P 〈 0.01）. Conclusion ： In coronary artery disease group, serum levels of cathepsin S, cystatin C increased significantly, cathepsin S is closely related to the severity of atherosclerostic lesions of coronary arteries, demonstrating that cathepsin S, cystatin C may be involved in the remodeling process of extracellular matrix.