血管细胞黏附分子-1和P-选择素对急性冠脉综合征的预测价值

Prediction value of serum VCAM-1 and serum P-selection in acute coronary syndrome

目的研究血清可溶性血管细胞黏附分子-1、P-选择素水平在急性冠状动脉综合征中的特点,探讨其对急性冠脉综合征的预测价值。方法用酶联免疫吸附法检测21例急性心肌梗死(AMI),23例不稳定型心绞痛,22例稳定型心绞痛(SAP)和20例健康对照者血清sVCAM-1、sP-选择素水平。结果ACS患者血清(UAP)sVCAM-1、sP-选择素水平均高于非ACS患者,AMI患者血清sVCAM-1浓度及sP-选择素水平较UAP患者升高(均P<0.05)。以x±2s为临界值联合检测ACS的灵敏度为73.4%,特异度为84.2%。结论ACS患者血清VCAM-1、P-选择素水平升高,提示与ACS的发生有关,是动脉粥样硬化斑块不稳定的标志,可以作为ACS的预测指标。

Objective To investigate the difference and relationships of serum VCAM-1 and P-selection levels in different subtype of coronary heart diseases and explore the potential predicting factors for the acute coronary syndrome （ACS）. Method The levels of serum sVCAM-1 and sP-selection in 21 cases of acute myo- cardial infarction （AMI） , 23 cases of unstable angina peetoris （UA） , 22 cases of stable angina peetoris （SA） and 20 cases of normal healthy control subjects were measured by ELISA method , eomparing the values of sVCAM-1 and sP-seleetion among different group. Result Serum sVCAM-1 and sP-seleetion levels were sig- nificantly higher in the ACS group compared with normal group. For ACS , the sensitivity was 73. 4 % , specificity was84. 2 % with serum sVCAM-1 and sP-seleetion levels. Conclusion The elevated VCAM-1 and P-selection levels suggested an obvious relationship with pathogenesis of ACS , which may be a potential markers of plaque instability and may be newly sensitive markers for identifying patients with ACS.