Survivin和Caspase-3在卵巢上皮性癌中的表达

Expression and significance of survivin and caspase-3 in epithelial ovarian cancer

目的:探讨Survivin和Caspase-3在上皮性卵巢癌发生发展中的作用。方法:采用免疫组织化学SP法,检测Survivin蛋白和Caspase-3蛋白在100例上皮性卵巢肿瘤中的表达。结果:①Survivin蛋白和Caspase-3蛋白在良恶性两组上皮性卵巢肿瘤中阳性表达率差异有显著性(P<0.05);②Survivin蛋白与恶性上皮性卵巢肿瘤的病理分级、临床分期有关(P<0.05),而与组织学类型无关(P>0.05),Caspase-3蛋白与恶性上皮性卵巢肿瘤的病理分级、临床分期及组织学类型均无关(P>0.05);③Survivin与Caspase-3两种蛋白在恶性上皮性卵巢肿瘤中的表达呈负相关关系。结论:①Survivin可能参与了上皮性卵巢癌的发生、发展过程,可成为具有潜在价值的肿瘤标志物。②Caspase-3可能在上皮性卵巢癌发生过程中起重要作用。③Survivin可能通过直接或间接抑制Caspase-3的活性阻断细胞凋亡过程从而导致上皮性卵巢癌的发生、发展。

Objective： To explore the relationship of survivin protein and easpase - 3 protein in epithelial ovarian neoplasms. Methods： Survivin protein and caspase - 3 protein were detected by immtmohistochemical SP technique in 100 cases of epithelial ovarian neoplasms, respectively. Results： （1）There was a significant difference of survivin protein and easpase - 3 protein expression between in benign tumor and in epithelial ovarian cancer （ P 〈 0. 05） . （2）The positive detection of survivin protein among the tissue types was not significantly different （ P 〉 0. 05） . There was significant difference among the Grades and Clincle Stages （ P 〈 0. 05） . There were no significant differences of caspase - 3 protein in ovarian cancer among all tissue types, various differentiation groups and clinical stages （P 〉 0. 05） . （3）Statistical analysis showed that the expression of survivin protein negatively correlated with caspase -3 protein in epthelial ovarian neoplasms. Conclusion： （1）Survivin might play roles in the process of carcinogenesis of epthelial ovarian cancers, and may be a potential tumor marker of ovarian cancer. （2）Caspase - 3 may play an important role in the carcinogenesis of epthelial ovarian cancers. （3）Survivin probably＇inhibit caspase -3 activation directly or indirectly to protect cells apoptosis from occurring, resulting in the occurring and progression of ovarian cancer.