精神分裂症患者神经递质变化的脑电超慢涨落仪分析

ET Analysis of Neurotransmitter Changes in Patients with Schizophrenia

目的应用脑电超慢涨落仪测定精神分裂症患者的神经递质的水平。方法应用脑电超慢涨落仪的生物化学物质振荡的原理,测定神经递质震荡的频率与周期,在脑电超慢波中记录该物质周期的次数,测定精神分裂症患者各种神经递质的水平。应用明尼苏达多相人格调查表(MMPI)和艾森克个性问卷(EPQ)进行人格测定。结果(1)两组受测者γ-氨基丁酸(GABA)、乙酰胆碱(ACH)、多巴胺(DA)和熵值间差别有统计学意义(P<0·05);(2)两组受测者MMPI中癔病(Hy)、妄想狂(Pa)、精神分裂症(Sc)和社会内向(Si)评分间差别有统计学意义(P<0·05);(3)两组受测者EPQ中精神质(P)和内外向(E)得分间差别有统计学意义(P<0·05)。结论(1)精神分裂症患者神经递质GABA和ACH水平降低,DA水平和熵值增高,提示了精神分裂症患者的脑电活动的无序状态,故可用脑电超慢波涨落仪检测精神分裂症患者的神经递质变化。(2)精神分裂症患者表现为明显的精神质、孤僻怪异特点。

Objective To determine the level of neurotransmitter of schizophrenia （SC） by ET to provide scientific basis for clinical medication. Methods The frequency and periodicity of neurotransmitter commotion were determined by the biochemical material commotion principle of ET, the frequency of the material periodicity was recorded and the level of every SC neurotransmitter was measured. The personality determination was performed by Minnesota Multiphasic Personality Inventory （MMPI） and Eisenck Personality Questionaire （EPQ）. Results （ 1 ） There was significant difference in gamma - aminobutyric acid （GABA）, acetylcholine （ACH）, dopamine （DA） and entropy value between the SC patients and the controls （ P 〈 0. 05） ; （2） In MMPI, the difference in the scores of hysteria （HY）, paranoia （PA）, SC and social introversion （SI） between the two groups was significant （ P 〈 0. 05 ） ; （3） In EPQ, significant difference was observed in the scores of nervous temperament and extroversion and introversion between the two groups （ P 〈 0. 05）. Conclusion （1） The decrease of GABA and ACH levels of neurotransmitters and the increase of DA level and entropy value suggest the disordered state of electrical activity of brain in SC patients. Therefore, ET can be used as one of the facilities in determining neurotransmitter changes in SC patients. （2） Obvious nervous temperament and unsociability are features of SC patients.