慢性乙型肝炎患者幽门螺杆菌感染状况分析

Helicobacter pylori seroprevalence in chronic hepatitis B patients

目的探讨慢性乙型肝炎患者幽门螺杆菌感染状况。方法采用病例对照研究的方法对502例慢性乙型肝炎患者的anti-HP-IgG和HBV DNA定量及分型进行检测。结果慢性乙型肝炎组(59.5%)、乙型肝炎肝硬化组(77.1%)及合并肝癌组(80.6%)HP感染率均明显高于健康对照组(43.4%),且随着病变程度的加重,HP感染率亦增加。不同病毒载量的慢性乙型肝炎患者HP感染率均高于HBV DNA(-)组(P<0.05)和健康对照组(P<0.001),但不同病毒载量之间比较无统计学差异。不同HBV基因型之间HP感染率无明显差异。结论慢性乙型肝炎患者幽门螺杆菌感染率明显增加,且随着病变程度的加重,HP感染率亦增加。

Objective To investigate the seroprevalence of helicobacter pylori in chronic hepatitis B patients.Methods In this case-control study,we searched for the HP prevalence and the quantitation and genotypes of HBV DNA in 502 chronic hepatitis B patients（357 males,145 females,mean age 34.2±13.2 years）.The controls were 429 sex and age matched healthy donors.All subjects were tested for presence in serum of IgG antibodies against HP and the result was analyzed using the chi-square test.Results HP seroprevalence was 59.5% in chronic hepatitis B group,77.1% in HBV-related cirrhosis group and 80.6% in HBV-related hepatocellular carcinoma group,respectively.The HP seroprevalence of three groups was higher than that in healthy controls（43.4%）.HP prevalence was increasing with the viral load of HBV DNA rising.The difference was not significant among the different genotypes of HBV.Conclusion HP prevalence was obviously increased in chronic hepatitis B patients,and it was higher with the viral load of HBV DNA.