2型糖尿病患者糖尿病肾病相关危险因素分析

Analysis over risk factors of diabetic nephropathy in 462 cases with type 2 diabetes mellitus

目的探讨2型糖尿病患者糖尿病肾病相关危险因素。方法应用多因素逐步回归的分析方法对380例2型糖尿病患者中186例糖尿病肾病(DN)和276例非糖尿病肾病(non-DN)患者有关危险因素(血压、血糖、胰岛素、三酰甘油及病程等)进行分析。结果DN组与非DN组比较,血压、血糖、胰岛素、三酰甘油、病程明显升高(P<0.05),多元回归分析显示,与DN相关的危险因素为舒张压、收缩压、空腹及餐后血糖、空腹胰岛素、三酰甘油和病程等。结论DN的发生与高血压、高血糖、高胰岛素血症、高血脂及病程相关。

[Objective] To study the correlated risk factors of diabetic nephropathy （DN） of type 2 diabetes. [Methods] 380 cases with type 2 diabetes in our hospital during the period of 2003-2006 were screened for diabetic nephropathy, and its correlated risk factors were analysed by multi-factor converse analyses. [Result] Through multi-factor converse analyses, We found that the factors in DN group is obviously higher than that of non-DN group in blood pressure, blood sugar, insulin ,glycerine trioleate and course of disease （P 〈0.05）. [Conclusion] Multi-factor converse analyse of this study show that the risk factors related with DN are diastolic pressure, fasting and postprandial plasma glucose, fasting insulin, glycerine trioleate, courses of diseases.