期刊文献+

生长激素缺乏和特发性矮小患儿血浆胃促生长素水平的变化 被引量:6

Changes of Plasma Ghrelin Levels in Children and Adolescents with Growth Hormone Deficiency and Idiopathic Short Stature
下载PDF
导出
摘要 目的探讨身材矮小儿童青少年血浆胃促生长素水平及胃促生长素在生长激素释放激素-生长激素(GHRH-GH)轴中的作用。方法抽取矮小症患儿157例。男115例,女42例;年龄3岁7个月-15岁1个月。取空腹静脉血10mL,分离出血浆标本,通过二种生长激素(GH)激发试验,将其分为3组,生长激素缺乏(CGHD)组37例,生长激素部分缺乏(PGHD)组52例,特发性矮小(ISS)组68例;在健康体检儿童中抽取20例年龄性别相匹配身高正常儿童为健康对照组。采用放射免疫法测定各组血浆中胃促生长素水平。采用ELISA法测定其血胰岛素样生长因子-1(IGF-1)水平。采用化学发光法测定其血清GH水平。分别测定其血睾酮、雌二醇、促黄体生成激素、促卵泡生成激素(FSH)水平。采用SPSS11.5软件对数据进行相关性分析。结果CGHD组患儿IGF-1水平明显低于其他3组,CGHD组患儿空腹血浆胃促生长素水平明显低于ISS组及健康对照组(Pa〈0.05),但与PGHD组无明显差异(P〉0.05)。胃促生长素水平与激发试验中GH峰值呈正相关(r=0.176P〈0.05),与FSH水平呈负相关(r=-0.163P〈0.05),而与其他因素无显著性相关(P〉0.05)。结论胃促生长素在GH分泌中起重要作用,其缺乏可能是下丘脑异常引起GH缺乏的原因之一。 Objective To explore the plasma ghrelin levels in children and adolescents with short stature and the role of ghrelin in growth hormone - releasing honaaone - growth hormone ( GHRH - GH) axis. Methods One hundred and fifty - seven children ( 115 male ,42 female) with short stature were selected. Fasting plasma sample was extracted fi'om 10 mL vemous blood of the children with short stature. Insulin tolerance test and arginine stimulation test was perfonaaed initially to differential diagnosis. And blood samples was divided into 3 categories:37 cases of complete growth hormone deficiency (CGHD) ,52 cases of partial growth hornone deficiency(PGHD) and 68 cases of idiopathic short stature(ISS) during these two growth hormone(GH) provocative tests. Controls consisted of age and gender-match 20 health children. Plasma ghrelin levels were measured by radioimmunoassay. Serum GH was detected by chemiluminescence method, and serum insulin - like growth factor - 1 ( IGF = 1 ) was measured by using enzyme linked immunosorbent assay. Fasting glucose, insulin, testosterone, estradiol ,luteinizing hormone ,follicle- stimulating hormone were measured. Statistical analysis were conducted by using SPSS 11.5 software. Resuits The fasting ghrelin levels of CGHD group Were significantly lower daan that of ISS group and control group(P 〈0.05 ) ,but had no difference with that of PGHD group ( P 〉 0.05 ). The ghrelin levels were positive correlated with the stimulated GH peak ( r = 0. 176 P 〈 0. 05 ), and were inversely correlated with FSH ( r = - 0. 163 P 〈 0.05 ). No other significant correlation was found( P 〉 0.05 ). Conclusion Ghrelin has an important role on GH secretion and abnormal secretion of ghrelin might be a reason of growth hormone deficiency which due to hypothalamic abnormality.
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2008年第8期588-589,592,共3页 Journal of Applied Clinical Pediatrics
基金 浙江省卫生厅医药卫生优秀青年科技人才专项基金项目资助(2006QN017)
关键词 胃促生长素 矮小症 生长激素缺乏 特发性矮小 儿童 ghrelin short stature growth hormaone deficiency idiopathic short stature child
  • 引文网络
  • 相关文献

参考文献13

  • 1Korbonits M, Grossman AB. Ghrelin:Update on a novel hormonal system [J]. Eur J Endocrinol,2004,151 ( suppl 1 ) : 67 - 70.
  • 2Kojima M,Hosoda H,Date Y,et al. Ghrelin is a growth - hormone - releasing acylated peptide from stomach [J].Nature, 1999,402(6762): 656 - 660.
  • 3Klok MD, Jakobsdottir S, Drent ML, et al. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: A review [J]. Obes Rev,2007,8 ( 1 ) :21 - 34.
  • 4Lengyel AM. From growth hormone -releasing peptides to ghrelin: Discovery of new modulators of GH secretion [ J ]. Arq Bras Endocrinol Metabol,2006,50 (1) : 17 - 24.
  • 5Dimaraki EV,jaffe CA. Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism[J]. Rev Endocr Metab Disord,2006,7 (4) :237 - 249.
  • 6Kineman RD, Luque RM. Evidence that ghrelin is as potent as growth hormone (GH) - releasing hormone (GHRH) in releasing GH from primary pituitary cell cultures of a nonhuman primate ( Papio anubis) , acting through intracellular signaling pathways distinct from GHRH[ J]. Endocrinology, 2007,148 ( 9 ) : 4440 - 4449.
  • 7de Vriese C,Delporte C. Ghrelin:A new peptide regulating growth hormone release and food intake[J]. Int J Biochem Cell Bio1,2007,3 [Epubahead of print].
  • 8Leite - Moreira AF, Soares JB. Physiological, pathological and potential therapeutic roles of ghrelin [ J ]. Drug Discos Today, 2007,12 ( 7 - 8 ) : 276 - 288.
  • 9沈红,梁黎,邹朝春,张嬿.不同生长激素激发试验时矮小男童血浆胃促生长素水平[J].中华内分泌代谢杂志,2007,23(1):55-56. 被引量:2
  • 10王慕逖.儿科学[M]5版[M].北京:人民卫生出版社,2001.125-129.

二级参考文献31

  • 1魏虹,梁雁,王慕逖.矮小儿童的生长激素胰岛素样生长因子轴功能的检查[J].中华儿科杂志,2005,43(2):99-103. 被引量:32
  • 2李堂.儿童特发性矮身材[J].实用儿科临床杂志,2005,20(6):607-608. 被引量:4
  • 3李堂,张颖,陈志红,梁进涛,郭萍,董增义,罗小平.国产r-hGH治疗儿童生长激素缺乏症的效果及其对病儿血糖、胃肠激素和维生素D代谢的影响[J].青岛大学医学院学报,2006,42(4):326-329. 被引量:5
  • 4Jarkovska Z,Rosicka M,Marek J,et al.Plasma levels of total and active ghrelin in acromegaly and growth hormone deficiency.Physiol Res,2006,55:175-181.
  • 5Korbonits M,Grossman AB.Ghrelin:update on a novel hormonal system.Eur J Endocrinol,2004,151:S67-S70.
  • 6Zizzari P,Halem H,Taylor J,et al.Endogenous ghrelin regulates episodic growth hormone (GH) secretion by amplifying GH pulse amplitude:evidence from antagonism of the GH secretagogue-R1a receptor.Endocrinology,2005,146:3836-3842.
  • 7Gondo RG,Aguiar-Oliveira MH,Hayashida CY,et al.Growth hormone-releasing peptide-2 stimulates GH secretion in GH-deficient patients with mutated GH-releasing hormone receptor.J Clin Endocrinol Metab,2001,86:3279-3283.
  • 8Giavoli C,Cappiello V,Corbetta S,et al.Different effects of short-and long-term recombinant hGH administration on ghrelin and adiponectin levels in GH-deficient adults.Clin Endocrinol (Oxf),2004,61:81-87.
  • 9Freemark M.Editorial:Growth hormone treatment of "idiopathic short stature":Not so fast[J].J Clin Endocrinol Metab,2004,89(7):3138-3139.
  • 10Cuttler L,Silvers JB.Growth hormone treatment for idiopathic short stature:Implications for practice and policy[J].Arch Pediatr Adol Med,2004,158(2):108-110.

共引文献77

同被引文献82

引证文献6

二级引证文献22

;
使用帮助 返回顶部