摘要
目的观察annexin A2在甲状腺癌不同病理类型中的表达及其与临床病理指标的关系。方法采用免疫组化EnVision法,在24例甲状腺乳头状癌、25例甲状腺滤泡癌、22例甲状腺髓样癌及24例结节性甲状腺肿中检测annexin A2的表达。结果乳头状癌中annexinA2的阳性率为45.8%(11/24),明显高于滤泡癌、髓样癌和结节性甲状腺肿中的阳性率(4%、9.1%、8.3%)(P<0.05)。annexin A2的表达在结节性甲状腺肿与滤泡癌髓样癌及滤泡癌与髓样癌之间无显著差异。乳头状癌中,annexin A2的表达与性别、年龄、淋巴结转移及远处转移无关。结论在甲状腺乳头状癌中annexin A2过表达,提示其可能参与甲状腺乳头状癌的发病机制。
Objective To study the expression of annexin A2 in different types of thyroid carcinoma and its relation with chnicopathological features. Methods The expression of annexin A2 was detected in 24 cases of thyroid papillary carcinoma, 25 thyroid follicular carcinoma, 22 thyroid medullary carcinoma and 24 nodular goiter. The results were analyzed statistically. Results The positive rate of annexin A2 was 45.8% in papillary carcinoma, which was significantly higher than that in follicular carcinoma, medullary carcinoma and nodular goiter （4%, 9.1% and 8.3% respectively）. No difference of the annexin A2 expression was observed among the follicular carcinoma, medullary carcinoma and nodular goiter. There was no apparent correlation between the expression level of annexin A2 and the chnicopathological features, such as age, gender, lymph node metastasis and distance metastasis. Conclusion annexin A2 is overexpressed in thyroid papillary carcinoma and it may play an important role in the carcinogenesis of thyroid papillary carcinoma.
出处
《诊断病理学杂志》
CSCD
2008年第2期117-120,共4页
Chinese Journal of Diagnostic Pathology
