摘要
目的研究移植肾切除对移植肾功能衰竭患者促红细胞生成素(EPO)抵抗的治疗作用。方法以移植肾功能衰竭进行规律性血液透析的患者为观察对象,在移植肾切除术前、术后采用EPO及补充造血原料治疗肾性贫血,检测患者血红蛋白、C反应蛋白、血清肌酐、血清铁蛋白水平。结果规律性透析患者移植肾切除术前采用EPO治疗3月血红蛋白水平改变不明显,血清C反应蛋白显著高于正常;移植肾切除后3月血红蛋白升高明显,血清C反应蛋白恢复正常,血红蛋白水平改变与C反应蛋白呈明显负相关。结论移植肾切除可逆转移植肾功能衰竭患者EPO抵抗,改善肾性贫血。
Objective To explore the effects of allograft nephrectomy on erythropoietin resistance in the patients returning to dialysis with a failed transplant, Methods All patients were treated with erythropoietin and enough iron, folic acid, vitamin B12 before and after allograft nephrectomy;haemoglobin value,serum C reactive protein, serum ferritin were measured. Results Before allograft nephrectomy the recipients returning to dialysis with failed transplant reacted poorly to erythropoietin treatment, with serum C reactive protein at high level; but 3 months after allograft nephrectomy haemoglobin value raised markedly, with serum C reactive protein returned to normal level. Conclusion Allograft nephrectomy can reverse erythropoietin resistance in the patients returning to dialysis with failed transplant.
出处
《中国药业》
CAS
2008年第9期52-53,共2页
China Pharmaceuticals
