胸腔内注入尿激酶治疗结核性胸膜炎的研究

Effect of intrapleural injection of urokinase in treatment of tuberculous pleurisy

目的探讨胸腔内注入尿激酶治疗结核性胸膜炎的效果。方法将40例结核性胸膜炎患者随机分为治疗组和对照组。治疗组在胸穿抽液后注入生理盐水20ml稀释尿激酶10万u,对照组在胸穿抽液后注入生理盐水20ml,两组抗结核化疗方案相同。结果治疗组抽液次数、抽液量、胸膜厚度、胸膜粘连度与对照组相比(P<0.01)有显著性差异。结论胸腔内注入尿激酶能显著增加胸液引流量、能有效降低胸膜肥厚、胸膜粘连的程度,与对照组相比有显著性差异。

Objective To investigate the effects of intrapleural injection of urokinase in treatment of tuberoulous pleural effusion. Methods The 40 eases with tuberculous pleural effusion were randomly divided into treatment group and control group. The eases in treatment group were treated with 100 000IU urokinase （diluted by 20ml normal saline） after draining effusion and those in the control group were only. given normal saline after draining of effusion. Results The effect in treatment group was significantly superior to those of the control group （ P〈0.01 ）. Conclusion Intrapleural urokinase is effective for treatment of patients with tuberculous pleurisy.