检测血小板参数在血小板减少性疾病中的意义

The significance of platelet parameters measurement in thrombocytopenia

目的探讨血常规检测中血小板(PLT)计数、血小板平均体积(MPV)及血小板分布宽度(PDW)在血小板减少性疾病中的意义。方法使用雅培CD-1800全自动血细胞分析仪进行检测。结果与健康对照组相比,在疾病组中,再生障碍性贫血PLT计数降低(P<0.01),MPV降低(P<0.01),PDW无变化;而急性白血病PLT计数降低(P<0.01),MPV降低(P<0.01);PDW升高(P<0.01);特发性血小板减少性紫癜(ITP)组中,PLT计数减少(P<0.01),MPV升高(P<0.05),PDW升高(P<0.01)。结论PLT、MPV、PDW在血小板减少性疾病的鉴别诊断中有较大的临床应用价值。

Objective To investigate the detection value of platelet parameters including platelet counts （PLT）, mean platelet volume （MPV） and platelet distribution width （PDW） in thrombocytopenia. Methods Abbott CD-1800 Hematology Analyzer was applied to measuring the platelet parameters including platelet counts （PLT）, mean platelet volume （MPV） and platelet distribution width （PDW）. Results Compared with those of the control group, platelet count and MPV were significantly lower in aplastic anemia （AA） group and acute leukemia group （P〈0.01）. PDW didn＇t change significantly in AA group, but increased markedly in acute leukemia group （P 〈0.01）. In idiopathic thrombocytopenic purpura （ITP） group, platelet count decreased significantly （P〈0.01）, while MPV and PDW increased obviously （P〈0.05 and P〈0.01）. Conclusion PLT, MPV and PDW are very useful parameters for differential diagnosis of thrombocytopenia.