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Toll样受体在机体抗病毒免疫反应中的作用 被引量：5

The roles of Toll-like receptors in anti-viral immunity
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摘要 哺乳动物的Toll样受体（TLR）家族具有模式识别受体的功能，其可以识别微生物的保守分子成分，启动机体的固有免疫系统，从而帮助机体清除病原体。利用TLR敲除的动物或细胞模型进行的研究使人们认识到TLR在机体抗病毒免疫反应中发挥着重要作用。病毒与宿主细胞的TLR结合后，通过NF-KB或IRF-3的信号路径激活细胞因子的表达，从而激发免疫应答。研究TLR如何与病原体结合及如何激活下游基因对深入认识病原体所致相关疾病的发病机制、免疫应答及病理生理具有重要的意义，并为病毒性疾病的临床治疗或免疫预防提供新的思路。 Toll-like receptors （TLR） play critical roles in initiating host innate immune system and eradicating the invading pathogens by recognizing conserved structures of microorganisms. TLR-deficient animal models and cell culture have provided us with immense knowledge on the function of TLRs in anti-viral innate immune responses. Viruses activate TLRs and induce immune response through NF-κB or IRF-3 signaling pathway. Research on the relationship between TLR and virus and the mechanism of activating signaling cascade genes will help us to further understand the immune response and the pathogenesis of infectious disease, and provide new insights to the therapy and prevention on viral disease.
作者 徐锦 杨毅(审校)
机构地区 复旦大学附属儿科医院儿科研究所
出处 《国际免疫学杂志》 CAS 2008年第3期221-225,共5页 International Journal of Immunology
关键词 TOLL样受体 病毒 免疫应答 Toll-like receptor（TLR） Virus Immune response
分类号 R3 [医药卫生—基础医学]
  • 相关文献

参考文献24

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二级参考文献17

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共引文献6

同被引文献72

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引证文献5

二级引证文献8

国际免疫学杂志
2008年 第3期

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