病毒IL-10的研究进展

Advancement in viral interleukin-lO

病毒IL-10（vlL-10）是EB病毒基因组中一段开放读码区BCRFl编码的蛋白质，约85％的氨基酸与IL-10相同，具有抗炎及免疫抑制等作用。vlL-10主要是通过下调或抑制免疫反应扩大的细胞因子来改善移植物的存活，有研究者将vlL-10转移到气管、心脏、角膜等器官，对其进行了抗炎、抗排斥等方面的研究，为vlL-10的临床应用提供了有力的实验依据。

Viral interleukin-10（vIL-10） is a protein encoded by EB virus in its open reading frame BCRF1. About 85% of its amino acids are the same as IL-10. vIL-10 also has anti-in- flammatory and immunosuppressive effects, vIL-10 improves the survival of transplanted or-gans primarily through the reduction or suppression of cytokines the immune response . Researches have been done on vIL-10 about its performance in anti-inflammatory and anti-rejection through transferring vIL-10 to trachea, heart, corneas and other organs. These studies provided a strong experimental basis.for the clinical application of vIL-10.