Diclazuril 对鼠的急性和亚急性毒性研究

STUDIES ON ACUTE AND SUBACUTE TOXICITIES OF DICLAZURIL IN MICE AND RATS

对昆明种小白鼠口服Ｄｉｃｌａｚｕｒｉｌ进行了急性毒性试验，测得小白鼠口服Ｄｉｃｌａｚｕｒｉｌ的ＬＤ５０大于１００００ｍｇ／ｋｇ。对ＳＤ系大白鼠进行Ｄｉｃｌａｚｕｒｉｌ的亚急性毒性试验，根据体重分别用１０、５０、１５０ｍｇ／（ｋｇ·ｄ）的剂量添加于饲料中通过６０ｄ混饲方式给药，分别于３０和６０ｄ抽检动物。检查内容为：一般情况观察和饲料利用率，器官系数和器官含水量，血液学指标，血液生化指标，尿液指标和病理解剖观察及组织学检查。试验结果表明Ｄｉｃｌａｚｕｒｉｌ对鼠的毒性很低，在６０ｄ的试验期内不随剂量的增大和使用时间的延长出现毒性加大的变化。急性毒性与亚急性毒性试验的结果相一致。

he acute toxicity of Diclazuril by oral administration was studied in Kunming mice. The oral LD_50 was over 10 000 mg/kg. Subacute toxicity test in SD rats was carried out by giving medicated feed with three different doses of 10,50,100 mg/(kg·d). The rats were killed and examined at 30th and 60th days after drug administration. The examinations included: general clinical observation, feed efficiency, coefficient and moisture content of organs, blood index, blood biochemical index, urine index, necropsy finding and histopathology. At 30th days animals in test groups manifested changes in some blood index (RBC、HGB) and blood biochemical index (BUN、Gluc). There were no siganificant changes between control and test groups at 60th days. The studies suggested that the toxicity of Diclazuril was low and showed no relationship between severity of the biochemical changes and duration of administration.