中老年男性血清性激素水平与动脉粥样硬化关系的探讨

Relationship between sex hormones and artherosclerosis in elderly men

目的:探讨中老年男性血清性激素水平变化及其与动脉粥样硬化发病间的关系。方法:中老年男性分为有和无颈动脉粥样硬化两组,年轻男性构成对照组,测定血浆总睾酮、雌二醇、促卵泡激素、促黄体生成素水平。结果:与对照组比较,中老年男性血睾酮水平显著降低,促卵泡素、促黄体生成素显著升高(P均<0.05),雌二醇水平无差异,但中老年男性动脉硬化组血睾酮与雌二醇之比值较无动脉硬化组显著降低(P<0.05)。结论:中老年男性动脉硬化发病与血雄激素水平降低有关。

Objective： To investigate the level of sex hormone and its relationship to artherosclerosis in elderly men. Methods： Study population consisted of elderly men with or without carotid artery artherosclerosis （34 cases, 31 cases respectively） and the 45 young peoples were regarded as control group. In all patients, levels of total testosterone, estradiol, luteinizing hormone （LH） and follicle stimulating hormone （FSH） were measured. Results： There were significant decrease in the level of testosterone and increase in levels of LH and FSH in elderly men （P〈0.05 all） com- pared with the control group, whereas no change in the level of estradiol. The value Of the ratio of testosterone to estradiol was significantly lower in the elderly men with artherosclerosis than that of without artherosclerosis （P 〈0.05）. Conclusion： These results indicate that the low level of testosterone and the related lower ratio of testosterone to estradiol are pathogenesis factor in atherosclerosis of elderly men.