血浆脑钠素水平对急性冠脉综合征预后的意义

Effect of brain natriuretic peptide level on risk stratification in acute coronary syndrome

目的:探讨血浆脑钠素(BNP)水平与急性冠脉综合征(ACS)预后的关系。方法:用酶联免役吸附法检测120例ACS患者[分为ST抬高心肌梗死(STEMI)组、无ST抬高心肌梗死(NSTEMI)组和不稳定心绞痛(UAP)组]入院和出院时血浆BNP水平,并与30例正常健康人(对照组)作对照,随访观察6个月。结果:血浆BNP水平:ACS患者STEMI组、NSTEMI组的明显高于UAP组,UAP组的高于对照组(P<0.05);发生心衰、死亡患者的血浆BNP水平高于未发生者(P<0.05);ACS患者经过治疗后血浆BNP水平低于治疗前(P<0.05)。结论:ACS患者血浆BNP水平明显升高,血浆BNP水平是ACS患者预后的预测因子,亦可作为判断ACS患者疗效及指导治疗的指标。

Objective： To evaluate the effect of brain natriuretic peptide level on risk stratification in acute coronary syndrome. Methods： By using ELISA, the plasma concentration of BNP in eighty patients with AMI was tested （AMI group）, and was compared with control of 30 healthy adults （control group）. Results： The plasma BNP concentra- tion of AMI patients was significantly higher than that in patients with unstable angina （UAP） and BNP level of UAP group was higher than that of control group （P〈0.05 all）. The BNP level was significantly higher in patients with cardiovascular accidental events than that without （P〈0. 05）. After treatment the BNP level significantly decreased （P〈0.05）. Conclusion.. The plasma BNP concentration significantly increases, and is a good index for risk stratification in patients with acute coronary syndrome.