纳洛酮对大鼠局灶性脑缺血再灌注损伤后的脑保护作用

Effect of Naloxone on protecting cerebral in rats with focal cerebral ischemia after reperfusion injury

目的:探讨纳洛酮对局灶性脑缺血再灌注损伤的保护作用。方法:24只Wister大鼠随机分为3组,采用腔内线栓法制备动物模型,检测纳洛酮治疗组及对照组髓过氧化物酶(MPO)含量。结果:大鼠脑缺血再灌注后脑组织MPO含量明显增加(P<0.05),应用纳洛酮后缺血侧脑组织MPO含量显著下降(P<0.05)。结论:纳洛酮可以减轻脑缺血再灌注损伤,纳洛酮具有神经保护作用。

Objective： To investigate the effect of Naloxone on protecting cerebral in rats with focal cerebral ischemia after reperfusion injury. Methods.. The 16 Wister rats were made manufacture as middle cerebral artery occlusion （MCAO） and randomly divided into two groups~ Naloxone treat group and normal saline treat group. Another 8 nor- mal Wister rats were regarded as normal control group. The myeloperoxidase （MPO） was detected in three groups. Results： The MPO levels of Naloxone treat group and normal saline treat group were significantly higher than that of normal control group （P〈0. 05）, and the MPO levels of Naloxone treat group significantly decreased compared with that of normal saline treat group （P〈0.05）. Conclusion： Naloxone can decrease reperfusion injury of rats with focal cerebral ischemia, and protecting cerebrum.