缬沙坦联合黛立新治疗老年原发性高血压患者的疗效

Effect of Valsartan combine with antidepressive drug on blood pressure and antidepression in aged hypertensive patient with depression

目的:观察缬沙坦联合黛立新治疗老年原发性高血压病伴抑郁症患者的降压疗效及其副作用。方法:114例老年原发性高血压伴抑郁症的患者被随机分为治疗组和对照组。治疗组58例,在口服缬沙坦80mg,1次/d的基础上,给予黛立新1片,1次/d,口服,共8周;对照组56例给予缬沙坦80mg,1次/d,口服。结果:(1)8周后治疗组降压总有效率为79%,而对照组总有效率57%,两组之间有显著性差异(P<0.05);(2)治疗组58例平均收缩压(SBP)/舒张压(DBP)下降(19.2±2.1)/(10.6±1.2)mmHg,而对照组56例下降(10.2±1.6)/(5.2±0.7)mmHg,治疗组下降幅度优于对照组(P<0.01);治疗组8周后Zung评分由(56.4±4.6)下降为(24.6±4.2),P<0.01;而对照组由治疗前的(57.5±4.5)下降为(55.6±4.3),P>0.05。结论:缬沙坦联合黛立新治疗老年原发高血压伴抑郁症患者,明显改善其抑郁状态,而且血压控制良好,优于单纯应用降压药。

Objective： To observe the effect of Valsartan combine with antidepressive drug on blood pressure and antidepression in aged hypertensive patient with depression. Methods： One hundred and fourteen hypertensive patients with depression were randomly divided into treatment group （n= 58） and control group （n= 56）. Patients in the control group were only treated with oral Valsartan 80mg/d; patients in the treatment group were treated with anti-depressant Flupentixol and Melitracen 1 tablet/d on the basis of Valsartan for 8 weeks. Results： （1） Eight weeks alter treatment the total effective rate of treatment group was 79%, it was significantly higher than that of control group （57%） , P〈0.05; （2） The mean SBP and DBP decreased （19. 2±2.1） / （10.6±1.2） mmHg in treatment group, significantly more than that of control group （10.2±1.6） / （5.2±0.7） mmHg （P〈0.01）; （3） Scores o[ Zung decreased from （57.5±14.5） to （24. 6±4. 2） in treatment group, it was more than that of control group [from （57. 5± 14. 5） to （55.6±4. 3） ], P〈0.01. Conclusion.. Valsartan combine with Flupentixol and Melitracen is effective not only anti-depression, but also decreasing blood pressure and it＇s effect more than that of hypotensive drug alone in hypertensive patients with depression.