摘要
目的从分子水平探讨中药红景天抗肝纤维化的疗效及可能抗纤机制。方法Wistar大鼠90只雌雄各半,随机等分三组:空白组、模型组和红景天组。以CCL4造模,用中药红景天灌胃进行治疗干预。检测肝组织中ALR mRNA(肝再生增长因子mRNA)表达量及组织病理情况,组织切片采用HE染色和VG染色。结果ALR mRNA的表达增强,红景天组与对照组比较两者有显著性差异(P<0.05)。肝组织病理学变化观察中药红景天组都在不同程度上缓解、逆转了肝纤维化的病变程度。结论中药红景天能显著通过促进ALR mRNA的表达可延缓或减轻肝硬化的发生。
Objective To study the molecular mechanism of treatment by Chinese herbs on the hepatic fibrosis of rats, Methods Hepatic fibrosis model of rats was established with CCIA. Then the rats were divided into control, model and Chinese herbs treated groups. The level of ALR mRNA expression and hepatic fibrosis parameters were observed from different groups. Results The level of ALR mRNA expression both in Chinese herbs treated group and model group were significantly higher than that in con- trol group （ P 〈 0.05 ）. After treatment by Chinese herbs, the level of ALR mRNA expression in liver tissues was higher than that of control group （ P 〈 0. 05 ）. Conclusions Our Chinese herbs significantly enhanced the ALR mRNA expression in liver of hepatic fibrosis rats.
出处
《实用肿瘤学杂志》
CAS
2008年第2期108-109,145,共3页
Practical Oncology Journal
