50例舌下含化米索前列醇辅以催产素对剖宫产后出血的效果观察

Effects of Misoprostol and Oxytocin on postpartum hemorrhage in uterine-incision delivery

目的观察舌下含化米索前列醇辅以催产素对剖宫产后出血的影响。方法选择100例有产后出血高危因素的产妇,随机分成两组即观察组和对照组,每组各50例。米索组(观察组)在胎儿取出后立即舌下含化米索前列醇200μg,再宫体注射催产素10u,静脉给予5%GS 500mL加催产素20u;催产素组(对照组)在胎儿取出后立即宫体注射催产素10u,静脉再给予5%GS500mL加催产素20u。观察两组在产后2、24h内平均出血量差异。结果观察组产后2h平均出血量(230.25±23.1)mL,24h平均出血量(338.87±54.3)mL;对照组产后2h平均出血量为(267.63±33.5)mL,24h平均出血量(419.89±57.6)mL。结论米索前列醇辅以催产素促进宫缩的作用明显强于单独使用催产素,且米索前列醇舌下含化方便、安全,吸收迅速能很好地预防高危因素引起的产后出血。

Objective To evaluate the effects of Misoprostol and Oxytoein on postpartum hemorrhage in uterine-incision delivery. Methods One hundred parturients with high risk of postpartum hemorrhage were divided into observation group and control group averagely. In observation group,the parturients were given sublingual administration Misoprostol,injected Oxytocin 10u in uterus and intravenous injection 5%GS 500μL＋ Misoprostol 20u immediately after uterine-incision delivery. In control group, the parturients were injected Oxytocin 10u on uterus and given intravenous injection 5%GS 500mL＋ Misoprostol 20u immediately after uterine-incision delivery. The volume of blood in both group after uterine-incision delivery in 2h and 24h were measured. Resuits The volume of blood were （230.25±23.1）mL in 2h and （338. 87±54.3）mL in 24h in observation group,while （267.63± 33.5）mL in 2h and （419.89±57.6）mL in 24h in control group. Conclusion Using of Misoprostol and Oxytocin can reduce the vob ume of postpartum hemorrhage after uterine-incision delivery,in comparison with single Oxytocin using.