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核苷类抗病毒靶向制剂的研究进展

Development of nucleoside and nucleotide analogues for antiviral targeting preparation
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摘要 目的综述核苷类靶向制剂研究进展。方法在查阅国内外文献得基础上,从被动靶向制剂方面进行探讨。结果与结论核苷类靶向制剂市场潜力巨大,有很好的应用和开发价值。 OBJECTIVE The development of nucleoside and nucleotide analogues for antivliral targeting preparation is reviewed. METHODS On the base of several literature,passive targeting preparation was approached. RESULTS and CONCLUSION The nucleoside and nucleotide analogues for antiviral targeting preparation have large market,its clinical application and development is restricted greatly.
作者 徐化平 张羽
机构地区 滕州市中医医院 邹城市人民医院
出处 《齐鲁药事》 2008年第4期231-233,共3页 qilu pharmaceutical affairs
关键词 被动靶向制剂 脂质体 纳米粒 微球 药质体 Passive targeting preparation liposome nanometerpill microsphere pharmacosome
分类号 R978.7 [医药卫生—药品]
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参考文献17

  • 1Engelmann C, Panis Y,Bolard J, et al. Liposomal encapsulation of ganciclovir enhances the efficacy of herpes simplex virus type lthymidine kinase suicide gene therapy against hepatic tumors in rats. Hum Gene Ther,1999,10(9) :1545-1551.
  • 2Law S L, Hung H Y. Properties of acyclovir-containing liposomes for potential ocular delivery. Int J Pharm, 1998, 161 (2) : 253- 259.
  • 3Law S L, Huang KJ,Chiang C H. Acyclovir-containing liposomes for pot ential ocular delivery:corneal penetration and absorption. J Controlled Release,2000,63 (122) :135-140.
  • 4Korba BA, Xie H, Wright K N, et al. Liver-targeted antiviral nuclecsides enhanced antiviral activity of phosphandyldideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infectione in vivo. Hepatology,1996,23(5):958-963.
  • 5Wang JX,San X,Zhang ZR. Enhanced brain targeting by synthesis of 3 ',5 '-dloctanoyl-5-fluoro-2 -deoxyuridine and incorporation into solid lipid nanoparticles, Eur J Pharm Biopharm, 2002,54(3) :285-290.
  • 6Emmanuel Riguet, Snehlata Tripathi, Binay Chaubey, et al. A Peptide Nucleic Acid- Neamine Conjugate That Targets and CleavesHIV-1TAR RNA Inhibits Viral Replication. J Med Chem,2004,47(2):4806-4809.
  • 7Giuseppina di stefano, corrado Busi,et al. Selective delivery to the liver of antiviral nucleoside analogs coupled to a high molecular mass lactosaminated poly- L- lysine and administered to mice by intramuscularroute. Biochemical pharmacology, 1995, 49 ( 12 ) : 1769-1775.
  • 8Dembri A,Montisci MJ,Gantier JC,et al. Targeting of 3'-azido 3' - deoxythymidine (AZT) - loaded poly ( isohexylcyanoacrylate) nanospheres to the gastrointestinal mucosa and associated lymphoid tissues. Pharm Res. 2001,18(4) :467-473.
  • 9Lobenberg R, Maas J, Kreuter J. Improved body distribution of 14C-labelled AZT bound to nanopartieles in rats determined by radioluminography. Drug Target, 1998,5 (3) : 171 - 179.
  • 10Zhang ZR, He Q. Study on liver targeting and hepatocytes permeable valaeielovir polybutyleyanoaerylatenanopartieles. World J Gastroenterol, 1999,5 (4) : 330- 333.

二级参考文献7

  • 1[1]Dienstag JL,Schiff ER,Mitchell M,et al.Extended Lamivudine retreatment for chronic hepatitis B[J].Hepatology,1996,24(1):188
  • 2[2]Muller RH,Mader K,Gohla S.Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art[J].Eur J Pharm Biopharm,2000,50(1):161
  • 3[3]Hashida M,Nishikawa M,Takakura Y.Hepatic targeting of drugs and proteins by chemical modification[J].J Controlled Release,1995,36(1/2):99
  • 4[4]Muller RH,Mehnert W,Lucks JS.Solid lipid nanoparticles (SLN)- an alternative colloidal carrier system for controlled drug delivery [J].Eur J Pharm Biopharm,1995,41:62
  • 5[5]Muller RH,Maassen S,Schwarz C.Solid lipid nanoparticles(SLN) as potential carrier for human use: interaction with human granulocytes[J].J Control Release,1997,47:261
  • 6[6]Muller RH,Ruhl D,Runge S,et al.Mehnert W.Cytotoxicity of Solid lipid nanoparticles as a function of the lipid matrix and the surfactant [J].Pharm Res,1997,14:458
  • 7[7]Schearz C,Mehnert W,Lucks JS,et al.Solid lipid nanoparticles (SLN) for controlled drug delivery.ⅠProduction,charecterazation and sterilization[J].J Control Release,1994,30(1):83

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齐鲁药事
2008年 第4期

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