隔离肝脏灌注治疗肝脏恶性肿瘤

Isolated hepatic perfusion for treatment of unresectable malignant tumor

Isolated hepatic perfusion(IHP)is the best re gional chemotherapy modal ity for treatment of unresectable liver primary cancer and liver metastases.The main principle of isolated hepatic chemotherapy is to achieve higher regional d rug concentrations and thus higher exposure of tumor tissue to the agents,resul ting in increased response rates,while shielding the organism from the systemic toxicity because of the much lower concentrations in the systemic circulation.At present the methods of IHP include surgical methods and methods with balloon c atheter technique,which promise to provide a micro-invasive procedure,bu t are not fully mature.The key point of successful IHP is low leakage or leakage-free.The more beneficial aspect of IHP is that it can simultaneously apply hyperthe r my and biologic agent TNF to improve sensitivity of chemotherapy,which is not p ossible in other regional chemotherapy.From previous literatures this overview is to describe the principle,procedure techniques,leakage monitor methods,hyp erthermy application,administration agents,therapeutic reaction,complications and perspective of IHP.

Isolated hepatic perfusion （IHP） is the best regional chemotherapy modality for treatment of unresectable liver primary cancer and liver metastases. The main principle of isolated hepatic chemotherapy is to achieve higher regional drug concentrations and thus higher exposure of tumor tissue to the agents, resulting in increased response rates, while shielding the organism from the systemic toxicity because of the much lower concentrations in the systemic circulation. At present the methods of IHP include surgical methods and methods with balloon catheter technique, which promise to provid procedure, but are not fully mature. The key point of successful IHP is low leakage or e a micro-invasive leakage-free. The more beneficial aspect of IHP is that it can simultaneously apply hyperthermy and biologic agent TNF to improve sensitivity of chemotherapy, which is not possible in other regional chemotherapy. From previous literatures this overview is to describe the principle, procedure techniques, leakage monitor methods, hyperthermy application, administration agents, therapeutic reaction, complications and perspective of IHP.