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鱼类内源性生长激素释放肽的研究进展 被引量：2

Advance in endogenesis ghrelin of teleosts
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摘要 生长激素释放肽(Ghrelin)是在哺乳动物中发现的第一个生长激素促分泌素受体的内源性配体,部分鱼类的Ghrelin基因和肽链结构已经被确定。与哺乳动物相似,鱼类Ghrelin的主要分泌部位也在消化道,但在脑、肾脏、鳃、心脏等组织中也有少量分泌。鱼类的Ghrelin参与多种生理功能的调节,包括促进摄食以及调节脑垂体内多种激素的分泌,可促进脑垂体分泌LH和GH,某些鱼类Ghrelin可能具有促进脑垂体分泌PRL的功能。本文综述了近年来鱼类Ghrelin结构与生理功能研究概况,旨在为丰富鱼类内分泌生理学研究提供参考资料。 Ghrelin was originally purified and characterized as the first identified endogenous ligand of the growth hormone secretagogue receptor in mammals. By now, the gene and peptide structures of ghrelin have been identified in several fishes. As in mammals, ghrelin is mainly secreted in the digestive tract of fish and there are minor levels of ghrelin secreted in the brain, kidney, gills, heart and other tissues, and it is involved in the regulation of a number of physiological functions, including stimulating food intake in fishes and modulating the release of pituitary hormone such as stimulating luteinizing hormone and growth hormone release from the pituitary in fishes, and stimulating the release of prolactin in pituitary in some fishes. This review summarized the research survey in the structure and physiological functions of ghrelin in fishes in recent years in order to provide reference for the enrichment of research content in endocrine physiology in fishes. [Journal of Fishery Sciences of China, 2008, 15 （3） ： 516-522]
作者 牟幸江 温海深 董双林
机构地区 中国海洋大学海水养殖教育部重点实验室
出处 《中国水产科学》 CAS CSCD 北大核心 2008年第3期516-522,共7页 Journal of Fishery Sciences of China
基金 国家"十一五"科技支撑计划课题(2006BAD09A01)
关键词 鱼 生长激素释放肽 内分泌 生理功能 fish ghrelin endocrine： physiological function
分类号 Q575 [生物学—生物化学]
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参考文献41

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同被引文献27

  • 1Liu F, Xia J H, Bai Z Y, et al. High genetic diversity and substantial population differentiation in grass carp (Ctenopharyngodon idella) revealed by microsatellite analysis[J]. Aquaculture, 2009, 297(1-4): 51-56.
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  • 3Chang M X, Nie P, Xie H X, et al. Characterization and expression analysis of TNF-related apoptosis inducing ligand (TRAIL) in grass carp Ctenopharyngodon idella [J]. Veterinary Immunology and Immunopathology, 2006, 110: 51-63.
  • 4Yang C R, Su J G, Huang T, et al. Identification of a retinoic acid-inducible gene I from grass carp (Cteno- pharyngodon idella) and expression analysis in vivo and in vitro[J]. Fish & Shellfish Immunology, 2011, 30(3): 936-943.
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  • 6Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach[J]. Nature, 1999, 402(6762): 656-660.
  • 7Naslund E, Hellstrom P M. Appetite signaling: From gut peptides and enteric nerves to brain[J]. Physiology and Behavior, 2007, 92(1-2): 256-262.
  • 8Unniappan S, Lin X, Cervini L, et al. Goldfish ghrelin: molecular characterization of the complementary deoxy- ribonucleic acid, partial gene structure and evidence for its stimulatory role in food intake[J]. Endocrinology, 2002, 143(10): 4143-4146.
  • 9Lawrence C B, Snape A C, Baudoin F M H, et al. Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers[J]. Endocrinology, 2002, 143(1): 155-162.
  • 10Tanaka M, Hayashida Y, Iguchi T, et al. Organization of the mouse ghrelin gene and promoter: occurrence of a short noncoding first exon[J]. Endocrinology, 2001, 142(8): 3697-3700.

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中国水产科学
2008年 第3期

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