摘要
目的:观察隔姜灸对肝郁脾虚型溃疡性结肠炎(ulcerative colitis,UC)大鼠结肠血管活性肠肽(vasoactive in-testinal polypeptide,VIP)、白介素-10(interleukin-10,IL-10)的影响。方法:三硝基苯磺酸(trinitro-benzene-sulfonicacid,TNBS)/乙醇溶液灌肠加束缚法制备大鼠肝郁脾虚型溃疡性结肠炎模型,进行隔姜灸实验性治疗,于第3周测定结肠VIP、IL-10的变化。结果:模型组结肠VIP明显增高,隔姜灸组较模型组含量明显降低(P<0.01),与柳氮磺吡啶组比较有显著性差异(P<0.05)。模型组结肠IL-10明显降低,隔姜灸组较模型组含量明显增高(P<0.01),与柳氮磺吡啶组比较有显著性差异(P<0.05)。结论:隔姜灸可能通过降低大鼠结肠VIP、增加大鼠结肠IL-10而达到治疗溃疡性结肠炎的目的。
Objective:To observe the effect of ginger moxibustion on the vasoactive intestinal polypeptide(VIP) and interleukin-10(IL-10) of ulcerative colitis(UC) rats with stagnation of liver-qi.Methods:A model of ulcerative colitis rats with stagnation of liver-qi was made by infusing rats with trinitro-benzene-sulfonic acid and alcohol solution for the ginger moxibustion experiment The change of VIP and IL-10 wrer determined three weeks later.Results:VIP of UC group obviously rose while VIP of ginger moxibustion group obviously reduced(P<0.01).Compared with Azulfidine group,the difference has significance(P<0.05).IL-10 of the UC group obviously reduced while IL-10 of the ginger moxibustion group obviously rose.Compared with Azulfidine group,the difference has significance(P<0.05).Conclusion:The ginger moxibustion may cure UC by reducing VIP and IL-10 of the UC rats.
出处
《云南中医中药杂志》
2008年第4期35-38,共4页
Yunnan Journal of Traditional Chinese Medicine and Materia Medica
