期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

急性脑出血患者血清和脑脊液胱抑素C变化及临床意义 被引量：11

下载PDF
导出
摘要 目的探讨血清和脑脊液胱抑素(CyaC)与急性脑出血的关系。方法分别测定66例脑出血患者为脑出血组,33例性别、年龄等与脑出血组匹配的非脑卒中者为对照组血清和脑脊液血浆CysC水平。结果脑出血组脑脊液胱抑素C含量低于对照组(P<0.01),均有显著性差异。有意识障碍患者脑脊液CysC低于无意识障碍患者(P<0.01);脑出血组血清CysC水平高于对照组(P<0.01),有意识障碍患者血清胱抑素C高于无意识障碍患者(P<0.01),均有显著性差异。结论脑脊液CysC水平降低,可作为反映血脑屏障损害的一个指标,血清和脑脊液CysC水平变化可反映脑出血患者的病情程度。
作者 方军 洪灵敏
机构地区 浙江省温岭市中医院检验科
出处 《实验与检验医学》 CAS 2008年第2期137-138,共2页 Experimental and Laboratory Medicine
关键词 脑出血 胱抑素C 血清 脑脊液
分类号 R446.112 [医药卫生—诊断学] R446.14 [医药卫生—诊断学]
  • 相关文献

参考文献11

  • 1[1]Eriksson P,Deguchi H,Samnegard A,et al.Human evidence that the Cystatin C gene is implicated in focal progression of coronary artery disease[J].Arterioscler Thromb Vasc Biol,2004,24:551～557.
  • 2孔宪涛.血浆蛋白质的检测和临床价值研究进展[J].江西医学检验,2001,19(2):99-103. 被引量：9
  • 3[3]Reed CH.Diagnostic applications of cystain C[J].Br J Biomed Sci,2000,57(4):323～329.
  • 4[4]Shtipak MG,Samak MJ,Katz R,et al.Cysmtin C and the risk of death and cardiovascular events among elderly persons[J].N Engl J Med,2005,352:2049～2060.
  • 5[5]Seliger SL,Longstreth WT Jr,Katz R,et al.Cystatin C and subclinical brain infarction[J].J Am Soc Nephrol,2005,16:3721～3727.
  • 6[6]GresserO,Weber E,HeUwig A,et al.Immunocompetent astrocytes and microglia display major differences in the processing of the invariant chain and in the expression of active eathepsin L and cathcpsin S[J].Eur J Immunol,2001,31:1813～1824.
  • 7李新毅,于为民,穆俊霞.急性期脑出血患者血尿素氮变化的观察[J].中国中西医结合肾病杂志,2001,2(9):529-530. 被引量：1
  • 8[8]Liu J,Sukhova GK,Sun JS,et al.Lysosomal cysteine pmtenses inatheroacleroais[J].Arterioseler Thromb Vase Biol,2004,24:1359～1366.
  • 9[9]Agantltna K Shirato I,Ishidoh K et al.Selective modulation of the secretion of proteinases and their inhibitors by growth factors in cultured differentiated podocytes[J].Kidney Int,2002,62(3):822～831.
  • 10史清海,路西春.胱抑素C的生物学特性及其测定的临床应用[J].西北国防医学杂志,2005,26(6):445-447. 被引量：33

二级参考文献18

  • 1Finney D, Newman DJ, Thakkar H, et al.Reference ranges for plasma cystatin C and creatinine measurements in premature infants, neonates, and older children[J].Arch Dis Child, 2000, 82:71-75.
  • 2Elise W, Pauli S, Raimo I, et al.Cystatin C as a marker of kidney dysfunction in an elderly population[J].Clin chem, 2002, 48(7):1138-1140.
  • 3Shimizu TA, Kobata M, Iovt H, et al.Serum cystatin C is a more sensitive marker of glomerular function than serum creatinine[J].Nephron, 2002, 92(1): 224-226.
  • 4Dharnidharka VR, Kwon G, Stevens G.Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis[J].Am J Kidney Dis, 2002, 40(2): 221-227.
  • 5Borut S, Levin V, Mirna S, et al.Improved prediction of decreased creatinine clearance by serum cystatin C: use in cancer patients before and during chemotherapy[J].Clin Chem, 2000, 46: 193-197.
  • 6Risch L, Blumberg A, Huber AR.Assessment of renal function in renal transplant patients using cystatin C[J].Ren Fail, 2001, 23: 439-448.
  • 7Michele M,Michele D,Vestra A.Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetes patients[J].Kidney Inter, 2002, 61(4): 1453-1461.
  • 8Lindholt JS, Erlandsen EJ, Henneberg EW.Cystatin C deficiency is associated with the progression of small abdominal aortic aneurysms[J].Br J Surg, 2001, 88: 1472-1475.
  • 9Per E, Hiroyuki D, Ann S, et al.Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease[J].Arteri Thromb Vasc Biol, 2004, 24:551-557.
  • 10Guido F, Friedrich P, Nathalie L, et al.β2-Trace protein, cystatin C, β2-Microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in children[J].Clin Chem, 2002, 48(5): 729-736.

共引文献39

同被引文献118

引证文献11

二级引证文献63

实验与检验医学
2008年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部