脂蛋白(a)与急性冠脉综合征的相关性探讨

Correlation between Lp (a) and acute coronary syndrome

目的探讨血清脂蛋白(a)与急性冠状动脉综合征(ACS)的相关性。方法入选150例同期住院患者,根据临床诊断分为非冠心病组(NCHD)38例;冠心病稳定型心绞痛组(SAP)28例;冠心病急性冠状动脉综合征组(ACS)84例,其中急性心肌梗死(AMI)38例、不稳定型心绞痛(UAP)46例。测定各组的血清脂蛋白(a)及血脂(TC及TG)并统计分析。结果(1)急性冠脉综合征组的血清脂蛋白(a)浓度高于非冠心病组(P<0.05)及稳定型心绞痛组(P<0.05);(2)血清脂蛋白(a)水平与血脂(TC及TG)没有相关性(P>0.05)。结论急性冠脉综合征者的血清脂蛋白(a)浓度较之非冠心病者及稳定型心绞痛者升高,且血清脂蛋白(a)浓度与血脂(TC及TG)水平没有相关性,提示血清脂蛋白(a)不仅是一种独立的冠心病危险因素,也可能促发了急性冠脉事件的发生。

Objective To explore the association between Lp （a） and acute coronary syndrome （ACS）. Methods Enrolled in the present study were 38 cases of NCHD, 28 cases of SAP, 38 cases of AMI and 46 cases of UAP. Serum concentrations of Lp （a） and lipids （TC and TG） were measured in each patient and compared between the groups. Results （1） Lp （a） level was significantly higher in patients with ACS compare with that in patients with NCHD （P〈0.05） or SAP （P〈0.05）; （2） No correlations were observed between Lp（a） level and serum levels of total cholesterol （TC） or triglycerides （TG）（P〉0.05）. Conclusions Serum Lp （a） concentration may be an independent risk factor for acute coronary syndrome .