1027例新疆汉族和维吾尔族住院患者代谢综合征及其代谢因子与慢性肾损害相关性研究

Study on the relationship between metabolic syndrome and chronic kidney disease in 1027 patients of Han and Uyguer people

目的探讨新疆地区汉、维两民族住院患者代谢综合征（MS）及代谢因子与慢性肾损害的关系。方法对2006年3月至2007年1月符合入选标准的1027例患者进行回顾性分析。按有无慢性肾脏疾病（CKD）及轻度CKD分组，比较汉、维族患者MS及代谢因子同CKD的关系。结果（1）在全部入选病例中汉、维族发生CKD构成比分别为37．4％和36．6％，轻度CKD的构成比分别为24．0％和25．3％；（2）CKD组及轻度CKD组一般情况的比较：汉族患者的年龄、LDL-C、尿酸（UA）、TG、HDL-C水平均高于维族，而BMI及SBP、DBP水平低于维族；（3）不同数量的代谢因子中汉、维族患者CKD发生的构成比无明显差别；（4）存在一种代谢紊乱中汉、维族患者均以糖尿病组CKD的构成比最高，存在两种及以上的代谢紊乱中汉族患者以高血压＋肥胖组合为主，而维族患者以糖尿病＋肥胖组合为主；（5）在轻度CKD组、CKD组中均以高血糖同CKD的关系最为密切。结论在汉、维族患者中CKD的发生均与MS及其代谢因子关系密切，在两民族患者中这种关系的差异无统计学意义。

Objective To investigate the relationship between metabolic syndrome and the chronic kidney disease in both Han and Uyguer populations. Methods 1027 cases were enrolled during 2006-3 to 2007-1 from the First Affiliated Hospital, Xinjiang University. According to the identification of chronic kidney disease （CKD） and minor renal dysfunction, these patients were divided into different groups. The correlation between the components of metabolic syndrome and CKD was examined. T test,Chi-square test and logistic regression were used. Results （ 1 ） CKD and mild CKD prevalence were 37.4 % and 24.0 % in all the cases. （2） The level of age, low-density lipoprotein cholesterol, trigly-ceride, high-density lipoprotein cholesterol, uric acid in Han people were higher than those among Uyguer people while body mass index, systolic blood pressure and diastolic blood pressure were lower than those Uyguer people. （3） There were no significant differences found between Han and Uyguer people in different metabolic components. （4） In the group which had only one metabolic component disjunction, the diabetic group accounted for big proportion while in those patients with two or more metabolic component disfunction, hypertension and obesity were significantly high in Han people but diabetes plus obesity were seen in Uyguer people. （5） Diabetes, obesity, metabolic components, uric acid were independent factors associated with CKD and mild CKD. Conclusion There were close connection between metabolic syndrome and CKD found in Xinjiang area.