结直肠癌肝转移的发生机制

Molecular Mechanism of Liver Metastasis from Colorectal Cancer

结直肠癌的发病率及死亡率在全世界以每年递增的趋势发展着,而其主要的死亡原因是肝转移。这一事件引起了众多学者的关注,大量研究也从各方面对其机理进行了论证。我们应用PubMed和MedLine,以及中国期刊网全文数据库(CNKI)两大文献检索文库,用"结直肠癌"、"肝转移"、"分子机制"等关键词进行检索,总结了近十年间有关结直肠癌的研究,试图提供一个结直肠癌肝转移的基本框架。本文中重点分析一些可能控制此事件的关键分子,对8类13项分子指标,包括基质金属蛋白酶、尿激酶型纤溶酶原激活剂受体、整合素、骨桥蛋白、肿瘤坏死因子相关凋亡诱导配体、干扰素-β、胰岛素样生长因子Ⅰ型受体、核基质蛋白、血管上皮生长因子、过氧化物酶体增殖物激活受体、胰岛素样生长因子、细胞外信号调节激酶和蛋白酶活化受体等与结直肠癌之间的关系进行了总结和分析,以期为寻找治疗和预测结直肠癌肝转移的新靶点提供新思路。

The morbidity and mortality of colorectal cancer are increasing over the world, while liver metastasis is the main cause of death. Many studies have elucidated the mechanisms. We searched the key words, such as colorectal cancer, liver metastasis and molecular factors, through PubMed, Medline and National Knowledge Infrastructure CNKI literature searching system, and discussed the studies in the recent decade. Thirteen well-identified and elucidated molecular factors, which belong to 8 categories, including matrix metalloproteinases, urokinase plasminogen activator receptor, intergin, osteopontin, tumor necrosis factor-related apoptosis-inducing ligand, interferon-β, insulin-like growth factor receptor 1, nuclear matrix protein, vascular endothelial growth factor, peroxisome proliferator-activated receptor-gamma, insulin-like growth factor, extracellular signal-regulated protein kinase and proteinase-activated receptors were reviewed in the article. Correlations of these molecular factors to colorectal cancer were summarized, which maybe helpful to give a new insight into the treatment and prediction of colorectal cancer with liver metastasis.