滇西纵谷野鼠鼠疫疫源地人群鼠疫F1抗体调查

Investigation on Plague F1-antibody in Sera of Population in Plague Natural Foci of Apodemus chevrieri and Eothenomys miletus in Yunnan Province

目的了解云南野鼠VNUNUMC疫源地人群鼠疫F1抗体的水平和分布情况。方法采集野鼠疫源地剑川县石龙村、长乐村的高危人群血清279份,同时采集5个县的非疫区人群血清235份作为对照,采用间接血凝试验进行检测,阳性判定标准为血清滴度≥1∶20。结果剑川县疫区高危人群检出鼠疫F1抗体阳性血清34份,阳性率为12.19%,其中2份为隐性感染,1份鼠疫历史病人血清滴度高达1∶640,鼠疫非疫区健康人群血清皆为阴性。结论此次野鼠鼠疫疫源地人群鼠疫F1抗体调查所检出的血清阳性滴度,可认为是主要由反复接种疫苗形成,但是也发现了少数未接种疫苗的血清阳性者,所以不可忽视该疫源地对人类的威胁,应加大监测和防护力度。

Objective To realize the level and distribution of plague F1 - antibody in sera of in plague natural foci of Apodemus chevrieri and Eothenomys miletus in Yunnan Province. Methods samples from high -risk population in plague natural foci and 235 serum samples from healthy po population 279 sera pulation in low - risk area were detected by indirect hemagglutination （ IHA ） with the diagnosis standard of positive titer no less than 1 ： 20. Results Out of 279 serum samples from the high - risk population, 34 samples were positive in plague F1 - antibody with the positive rate of 12.19%. 2 positive samples were caused by silent infec- tion and the positive titer of one rehabilitated patient was 1 ： 640. 235 serum samples of healthy people from non - plague area were all negative. Conclusions The positive titers detected in this survey of plague F1 - antibody in sera of population from the plague natural foci result from repeated inoculation of plague vaccine. However, a few people with serum F1 - positive have not inoculated the plague vaccine. So the threaten of the plague natural foci can not be ignored and the surveillance and protection of plague should be strengthened.