摘要
目的了解乌鲁木齐市7区1县健康人群A群、C群流行性脑脊髓膜炎(流脑)IgG抗体水平情况。方法采用酶联免疫吸附试验(ELISA)方法,对525份血清样本进行IgG抗体水平检测。结果A群流脑抗体总阳性率为26.29%,抗体几何平均滴度(GMT)为1:1.42;仅5-岁组与35-岁组有显著性差异(X^2=31.82,P〈0.01)。C群抗体总阳性率为13.33%,GMT为1:1.18。结论流脑A群、C群获得免疫性较低,平均流脑抗体水平阳性率为39.62%,GMT为1:1.68,对于防止脑膜炎球菌的感染保护作用低。为提高人群免疫力,建议将A+C群脑膜炎球菌多糖菌苗纳入儿童计划免疫程序,并对菌苗接种后的人群进行流脑抗体水平的随防监测。
Objective In order to explore the IgG antibody level against A and C epidmic cerebrospinal meningitis among healthy population in 7 regions and 1 county of Urumqi area. Methods Five hundred and twentyfive samples of sera from healthy population were collected and detected the serogroup A and C specific IgG antibody by ELISA. Results The result showed that the positive rate of seragroup A antibody was 26.29% and the GMT was 1: 1.42. There were significant differentces in GMT among 5 - year - old group and 35 - year - old group (X^2 =31.82, P〈0.01). The positive rate of C antibody was 13.33% with the GMT of 1: 18. Conclusions The acquired immunity of the group A and C epidemic cerebrospinal meningitis is low, the average positive rate of the antibody level of cerebrospinal meningitis is 39.62% and the GMT is 1: 1.68. It hasnt any protectable effect on cerebrospinal meningitis. We suggest that the group A and C of meningitis bacterium should incorporate to the immune project, and the surveillance will be continue to the serogroup A and C specific IgG antibody.
出处
《地方病通报》
2008年第2期33-34,36,共3页
Endemic Diseases Bulletin
关键词
流行性脑脊髓膜炎
A群
C群
抗体水平
监测
Epidemic cerebrospinal meningitis
Group A and C, antibody level
Surveillance