山区农村居民恶性肿瘤疾病负担的估计

Estimating the Burden of Malignant Neoplasm on Village Residents in a Mountainous Area

目的应用伤残调整寿命年（DALY）对临朐县农村恶性肿瘤疾病负担进行评价。方法以1998～2004年临胸县农村肿瘤登记资料为基础，利用全球疾病负担研究中使用的专门公式计算恶性肿瘤的YLLs、YLDs和DALYs，以此评价各类恶性肿瘤的疾病负担。结果临朐农村每千人每年因恶性肿瘤造成20．0个DALYs损失（男性24．82，女性14.96），其中92.5％为早死所致，7．5％因残疾所致；恶性肿瘤主要导致45～59岁人群的DALYs损失，占31．5％；恶性肿瘤疾病负担前10位依次为胃癌、肺癌、肝癌、食道癌、白血病、肠癌、脑癌、胰腺癌、乳腺癌和骨癌，其中仅胃癌、肺癌和肝癌三大肿瘤DALYs就占全部肿瘤的69．3％；临朐县农村恶性肿瘤疾病负担有进一步上升的趋势。结论恶性肿瘤疾病负担主要由早死所致，胃癌、肺癌、肝癌等主要癌症疾病负担高于全球和中国区水平。

Objective To make a comprehensive estimation of the burden of malignant neoplasm on village residents in Linqu County by the means of DALY （Disabillty-adjusted life year）. Methods DALYs, YLLs and YLDs were calculated following the procedures developed for the Global Burden of Disease （GBD） study to ensure comparabiliw, based onthe cancer registration data of Linqu villages during 1998--2004, in order to measure the burden of various caners. Results All cancers were responsible for 20.00 DALYs for every thousand population in Linqu County （24.82 for men and 14.96 for women）. 92.5% of the losses were due to premature death and 7.5 % to disability. 31.5 % of the DALYs happened among 45-59 age group. The top 10 cancers for DALYs were stomach cancer, lung cancer, liver cancer, oesophagus cancer, leukemia, colon/rectum cancer, brain cancer, pancreas cancer, breast cancer and bone cancer in turn. Only stomach cancer, lung cancer and liver cancer together account for 69.3 % of total DALYs due to malignant neoplasm. The burden of malignant neoplasm was on rising recent years. Conclusion The burden of disease of malignant neoplasm is mainly because of premature death. Stomaeh cancer, lung cancer and liver cancer lead to heavier burden than the global and national levels.