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抗肿瘤坏死因子-治疗失α败的困惑和新挑战 被引量:2

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摘要 自从1998年肿瘤坏死因子-α(tumornecmsisfator-alpha,TNF—α)拮抗剂的出现为临床上治疗常见风湿免疫性疾病如类风湿关节炎(RA)、强直性脊柱炎(AS)和其他系统性、炎性疾病带来了革命性进展以来,无论是改善疾病的临床症状还是控制病情进展方面的疗效令人振奋。但临床还会遇到许多大家关注的新的经验和新的难题,有关几个共识和进展值得和大家探讨。
作者 古洁若
出处 《中华风湿病学杂志》 CAS CSCD 2008年第5期291-293,共3页 Chinese Journal of Rheumatology
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参考文献5

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同被引文献13

  • 1McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol, 2007, 7: 429-442.
  • 2Barkauskaite V, Ek M, Popovic K, et al. Translocation of the novel cytokine HMGB1 to the cytoplasm and extracellular space coincides with the peak of clinical activity in experimentally UV- induced lesions of cutaneous lupus erythematosus. Lupus, 2007, 16: 794-802.
  • 3Ek M, Popovic K, Harris HE, et al. Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sjogren's syndrome. Arthritis Rheum, 2006, 54: 2289-2294.
  • 4Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatoid Association 1957 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum, 1988, 31: 315-324.
  • 5Morkve O, Learun OD. Flow cytometric measurement of P53 protein expression and DNA content in paraffin embedded tissue from bronchial carcinomas. Cytometry, 1991, 12: 438--444.
  • 6Yang H, Wang HC, Czura C J, et al. The cytokine activity of HMGB1. J Leukoc Biol, 2005, 78:1-8.
  • 7Gardella S, Andrei C, Ferrera D, et al. The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesiclemediated secretory pathway. EMBO Reports, 2002, 3: 995-1001.
  • 8Miseh EA, Hawn TR. Toll-like receptor polymorphisms and susceptibility to human disease. Clin Sci (Lond), 2008, 114: 347- 360.
  • 9Bianchi ME, Manfredi AA. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev, 2007, 220: 35-46.
  • 10Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol, 2006, 6: 823-835.

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