强直性脊柱炎患者疲乏症状的评定

Assessment of fatigue in patients with ankylosing spondylitis

目的评价强直性脊柱炎（As）患者疲劳症状的发生率，并探讨发生疲劳的相关因素。方法应用BathAS疾病活动指数（BASDAI）量表中的疲劳项目对AS患者的疲劳症状进行评分，评价AS患者疲劳的发生率，并探讨其与临床评价指标BASDAI、BathAS功能指数（BASFI）、BathAS测量指数（BASMI）、脊柱痛、夜间痛、脊柱炎症、肌腱端指数、整体关节肿胀指数、生活质量及实验室炎性指标红细胞沉降率（ESR）、C反应蛋白（cRP）的相关性。结果共纳入73例AS患者，将患者根据疲劳症状评分分为≥5分组和〈5分组，其中68．5％的患者疲劳项目的评分≥5分，≥5分组和〈5分组相比年龄、性别、病程等差异无统计学意义。双变量相关分析表明疲劳与疾病活动性、功能状况、脊柱痛、夜间痛及BASMI相关，与生理健康的4个维度及心理健康的1个维度相关，与ESR、CRP无相关性。结论疲劳是AS患者的一个重要的症状，应用BASDAI量表中的疲劳项目评分可以较好地进行疲劳症状评定。

Objective To investigate the prevalence of fatigue in AS and its relationship with other clinical and functional parameters used for the evaluation of disease activity. Methods The fatigue was assessed in 73 patients with active AS using a single-item fatigue question of BASDAI. The correlation between fatigue and the clinical parameters of disease including the Bath AS disease activity index （BASDAI）, Bath AS functional index （BASFI）, Bath AS metrology index（ BASMI ）, night pain, spinal inflammation, patient＇s global assessment （PGA） and enthesis index （EI） were determined. Results A total of 73 patients with ankylosing spondylitis were recruited. The prevalence of fatigue was 90.4% and the fatigue score of 68.5% patients was higher than 5. After controlled for the possible confounding factors such as age, gender, age and disease duration, it was found that fatigue was highly correlated with disease activity, pain and functional disability, BASMI, physical health and mental health. Conclusion Fatigue is an important symptom in AS. Fatigue can be measured with a single-item fatigue question of BASDAI.