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大鼠肝星状细胞转化生长因子β3／β1mRNA比值与Ⅰ型胶原合成的关系 被引量：1

Relationship of the transforming growth factor beta 3/beta 1 mRNA ratio and collagen I synthesis in rat hepatic stellate cells
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摘要 转化生长因子β1（TGFβ1）是激活肝星状细胞（HSC）并促进其胶原合成的最重要因子。TGFD3被认为具有抗组织纤维化的功能。Carrington等研究提示：TGFβ1与TGFβ3的比值是纤维化发生程度的关键因素。
作者 李琪 周霞 余姣 钱伟 徐可树
机构地区 华中科技大学同济医学院附属协和医院消化内科
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2008年第5期397-398,共2页 Chinese Journal of Hepatology
基金 国家自然科学基金（30570820）
关键词 肝纤维化 转化生长因子Β 肝星状细胞 Ⅰ 型胶原 Liver fibrosis Transforming growth factor beta Hepatic stellate cell Collagen Ⅰ
分类号 R575 [医药卫生—消化系统]
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参考文献5

  • 1Carrington LM, Albon J, Anderson I, et al. Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors. Invest Ophthalmol Vis Sci, 2006, 47: 1886- 1894.
  • 2周霞,余姣,李琪,钱伟,徐可树.重组转化生长因子β3基因对大鼠肝星状细胞Ⅰ型胶原表达的影响[J].中华肝脏病杂志,2008,16(1):43-48. 被引量：6
  • 3Hosokawa R, Nonaka K, Morifuji M, et al. TGF-beta 3 decreases type Ⅰ collagen and scarfing after labioplasty. J Dent Res, 2003, 82: 558-564.
  • 4Shek FW, Li KF, Mann J, et al. Transforming growth factor-beta3 (TGF-β3) expresses anti-fibrotic properties in pancreatic stellate cells. Gut, 2004, 53(supplement) : A16.
  • 5Li WY, Huang EY, Dudas M, et al. Transforming growth factor-beta3 affects plasminogen activator inhibitor-Ⅰ expression in fetal mice and modulates fibroblast-mediated collagen gel contraction. Wound Repair Regen, 2006, 14:516-525.

二级参考文献13

  • 1Gressner AM, Weiskirchen R. Modem pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med, 2006, 10: 76-99.
  • 2Hosokawa R, Nonaka K, Morifuji M, et al. TGF-beta 3 decreases type Ⅰ collagen and scarring after labioplasty. J Dent Res, 2003, 82: 558-564.
  • 3Related Articles, LinksReeves HL, Friedman SL. Activation of hepatic stellate cells--a key issue in liver fibrosis. Front Biosci, 2002, 7: d808-826.
  • 4Liu X, Hu H, Yin JQ. Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis. Liver Int, 2006, 26: 8-22.
  • 5Cao Q, Mak KM, Lieber CS. DLPC decreases TGF-beta1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol, 2002, 283: G 1051-1061.
  • 6Hernandez-Canaveral I, Gonzalez J, Lopez-Casillas F, et al. Amplified expression of dominant-negative transforming growth factor- beta type Ⅱ receptor inhibits collagen type Ⅰ production via reduced Smad-3 activity. J Gastroenterol Hepatol, 2004, 19: 380-387.
  • 7Parker JA, Brunner G, Walboomers XF, et al. Release of bioactive transforming growth factor beta(3) from microtextured polymer surfaces in vitro and in vivo. Tissue Eng, 2002, 8: 853-861.
  • 8Slemp AE, Kirschner RE. Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management, Curr Opin Pediatr, 2006, 18:396-402.
  • 9Kohama K, Nonaka K, Hosokawa R, et al. TGF-beta-3 promotes scarless repair of cleft lip in mouse fetuses. J Dent Res, 2002, 81: 688-694.
  • 10Shek FW, Li KF, Mann J, et al. TGF beta 3 expressing anti-fibrosis properties in pancreatic stellate cells. Gut, 2004, 53 Suppl: A16.

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中华肝脏病杂志
2008年 第5期

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