低密度脂蛋白胆固醇水平与帕金森病的关系

Research about relationship between low density lipid cholesterol levels and Parkinson's disease

目的探讨低密度脂蛋白胆固醇与帕金森病(PD)的关系。方法对门诊就诊的PD患者及健康对照者进行一般情况调查,并抽血化验胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇。对两组检查结果进行统计分析,对所有可能与PD发病有关的因素纳入Logistic回归分析。结果PD组血脂各项指标均低于正常对照组,但无统计学意义;Logistic回归分析显示家族史与PD发病有阳性关联。结论低密度脂蛋白胆固醇与PD发病之间的关系尚待研究,家族史是PD发病的危险因素之一。

Objective To investigate the relationship between LDL-C and PD. Methods Case-control study were carried out. Fasting lipid profiles were obtained from 54 PD cases and 50 controls, and the PD eases were recruited from eases presenting at our PD clinic, and controls were recruited from the medical examination populations of the same clinic. Results The triglyeerides ,total cholesterol,HDL-C and LDL-C were lower than control group, however did not reach significant difference. The family history related to PD by Logistic analysis（P〈0.05）. Conclusions No relationship is confirmed between LDL-C and PD,and the family history is a risk factor to PD.