肠易激综合征结肠黏膜P物质和血管活性肠肽变化的研究

Changes of Colonic Substance P and Vasoactive Intestinal Polypeptide in Irritable Bowel Syndrome

目的探讨肠易激综合征(IBS)患者结肠黏膜P物质(SP)、血管活性肠肽(VIP)的变化及其在IBS中的可能作用。方法对正常人18例I、BS腹泻型患者20例、便秘型患者22例各取回盲部、乙状结肠黏膜作SP、VIP免疫组织化学染色。结果IBS组患者肠黏膜SP、VIP免疫反应阳性神经纤维较正常对照组增多、增粗,强度增强(P<0.05)。结论IBS患者结肠黏膜SP、VIP水平与腹泻或便秘症状有一定的联系,SP、VIP可能参与IBS的病理、生理过程。

Objective： To investigate the changes of substance P （SP） and vasoactive intestinal polypeptide （VIP） ergic terminals in ileocecal （ICJ） and the sigmoid colon mucosa in irritable bowel syndrome （IBS）, and to study their possible roles. Methods The biopsies of the ICJ and the sigmoid colon were specifically stained with irnrnunohistochemistry for the neuropeptide-postive terminals in 18 healthy controls and 42 patients with IBS. Results Compared with that of the controls, in the colon biopsies from IBS patients, the terminals of SP and VIP in the lamina propria were markedly increased in density and in degree of immunostaining （ P 〈 0.05）. Conclusion SP and VIP levels of colon mucosa in patients with IBS may be related to diarrhea and constipation. SP and VIP might be involved in the pathophysiological mechnism of IBS.