盐酸苯海索与阿普唑仑治疗血液透析患者合并不宁腿综合征的对照研究

The contrast study between trihexyphenidyl hydrochloride and alprazolamum on hemodialytic patients with restless legs syndrome

目的探讨血液透析患者合并不宁腿综合征的有效治疗方案。方法将合并不宁腿综合征的血液透析24例患者，分别给予盐酸苯海索与阿普唑仑两种治疗，观察两组治疗前后国际RLS评估量表评分的变化以及对睡眠改善等指标。结果血液透析患者中RLS患病率达到19．2％，盐酸苯海索组在减轻症状（7．2±2．5vs16．8±7．3），减少睡眠／醒时腿动较佳乐定组更为有效（83．3％vs25％，100％vs21．4％），改善睡眠障碍两者差异不大，应用两种药物前后电解质和肾功能变化不大。结论盐酸苯海索能有效减轻血液透析患者合并不宁腿综合征的症状，明显优于阿普唑仑。

Objective To study an effective therapy for hemodialytic patients with restless legs syndrome. Methods 24 patients were divided into alprazolamum group（16） and trihexyphenidyl hydrochloride group（ 8 ）. Symptom changes was evaluated with international restless legs scale, and sleep quality was compared between two groups. Results The morbidity of restless legs syndrome in hemodialytic patients was 19.2%. Better symptom improvement （7.2 ±2.5 vs 16.8 ±7.3）,and better sleep quality（83.3% vs 25%,100% vs 21.4% ） were found in Trihexyphenidyl Hydrochloride group without severe adverse reaction on electrolyte and renal function. Conclusion Trihexyphenidyl hydrochloride was more effective than alprazolamum for hemodialytic patients with restless legs syndrome.