短期抗甲状腺药物治疗与抗中性粒细胞胞浆抗体关系的研究

The preliminary study on relation between short-term treatment by anti-thyroid drug and against neutrophil cytoplasmic antigens

目的探讨甲状腺功能亢进症(简称甲亢)患者治疗前后抗中性粒细胞胞浆抗体(ANCA)检出情况及其与短期抗甲状腺药物治疗的关系。方法将60例初诊Graves病甲亢患者治疗前作为未治疗组(n=60),治疗后归为治疗组(n=10),40例非甲亢健康人群作为对照组(n=40)。用间接免疫荧光法(IIF)检测血清ANCA及抗核抗体(ANA)。结果2例初诊未治疗甲亢患者ANCA-IIF阳性,10例治疗前ANCA阴性患者药物治疗6个月后及健康人群未检测出ANCA,患者与健康人群差异无统计学意义(P>0.05)。所有血清ANA均阴性。结论ANCA与Craves病本身可能无关,以及短期抗甲状腺药物治疗可能不诱发ANCA。

Objective To investigate the detection of Against Neutrophil Cytoplasmic Antigens （ANCA） before and after treatment in patients with hyperthyroidism,and the relation with short-term treatment by anti-thyroid drug. Methods 60 cases with graves disease before treatment was untreated group （ n = 60） , after treating by anti-thyroid drug these 10 cases would be as treatment group（ n = 10） ,40 healthy people served as control group（ n = 40）. ANCA and ANA （Antinuclear Antibody）were detected by indirect immunofluorescence （ⅡF） experiments. Results ：2 cases with graves disease who were newly diagnosed were ANCA-ⅡF（ ＋ ）. ANCA had not be detected in both 40 healthy people and the 10 cases who were ANCA-ⅡF（-） before treating by anti-thyroid drug for 6 months. ANA had not be detected in these 3 groups. Conclusion ANCA may irrelevant with graves disease,and short-term treatment by anti-thyroid drug may not induce ANCA.