长春瑞滨与顺铂联合同步三维适形放疗治疗非小细胞肺癌临床分析被引量：1

Clinical study of three-dimensional conformal radiotherapy combined with chemotherapy of Navelbine and Cisplatin

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摘要目的观察长春瑞滨和顺铂联合同步三维适形放疗治疗非小细胞肺癌(NSCLC)的疗效。方法90例符合NSCLC诊断标准的患者随机分为两组,治疗组45例,对照组45例。两组在常规治疗的基础上,治疗组给予长春瑞滨和顺铂静脉滴注,并同步三维适形放疗,对照组给单纯适形放疗。结果治疗组CR18例(40.00%),PR21例(46.67%),SD5例(11.11%),PD1例(2.22%)有效率(CR+PR)86.67%;对照组CR7例(15.56%),PR17例(37.78%),SD18例(40.00%),PD3例(6.66%),两组差异有统计学意义(P<0.05)。结论长春瑞滨和顺铂联合同步三维适形放疗的疗效显著,且不良反应可以耐受。 Objective To explore the therapeutic value of three-dimensional conformal radiotherapy （3D-CRT） combined with chemotherapy of Navelbine and Cisplatin in the treatment of non-small cell lung cancer （NSCLC）. Methods According to the different grades and characteristic of organism of NSCLC, we treated 45 NSCLC patients by 3D-CRT alone as control group. Another group of 45 patients （as therapy group） with non-small cell lung cancer was treated by 3D-CRT combined with chemotherapy of Navelbine and Cisplatin. Results In therapy group, CR=18 cases（40% ） , PR：21 cases（46.67% ） , SD：5 cases（ 11.11% ） , PD： 1 patient （2.22%） , C R ＋ PR：39 cases（ 86.67% ）. In the control group, 45 N SCLC cases were treated by 3 DCRT alone, CR ：7 cases （ 15.56% ） , PR ： 17 cases （ 37.78% ） , SD ： 18 cases （40.00%） , PD ：3 cases （ 6.66% ） , CR ＋ PR ： 24 cases （53.3%）. The difference shows significant （ P 〈 0.05 ）. Conclusion Three-dimensional conformal radiotherapy combined with chemotherapy of Navelbine and Cisplatin for NSCLC was preferable and the toxicity was tolerable.

作者陈利军单梅霞左予武莉萍高国伟

机构地区河南省新乡市中心医院放疗科

出处《中国实用医药》 2008年第13期32-33,共2页 China Practical Medicine

关键词非小细胞肺癌三维适形放射治疗症状临床分析 Non-small cell lung cancer Three dimensional conformal radiotherapy

分类号 R734.2 [医药卫生—肿瘤]

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