血管生成素研究进展

Angiogenin:its research advances

血管生成素(angiogen in,ANG)是一种重要的血管生成因子,属于RNase超家族的一员。它的立体结构包含3个功能元件:RNase活性中心、细胞表面受体结合位点和核定位序列。ANG能有效地促进血管新生,并参与调控其他血管生成因子。它还具有RNase活性,故有抑制蛋白合成等作用。ANG促血管生成途径包括:经典的细胞信号转导途径和核转位途径。ANG参与多种生物学过程,特别是肿瘤的增殖与血管新生。

Angiogenin is an important angiogenic factor and a member of RNase superfamily. Angiogenin has three essential functional elements in its stereochemical structure ：the ribonucleoytic active site, the cell-binding site and the nuclear location site. Angiogenin can effectively promote tubular morphogenesis and regulate other angiogenic factors. Its weak ribonuleoytic activity can also inhibit the composition of protein. There are two modes of its angiogenesis： the classic cell transduction pathway and the nucleic localization pathway. Angiogenin plays an important role in many biological conditions, especially in the proliferation of tumor cells and the morphogenesis of new blood vessels.