survivin在胃肠道间质瘤中的表达及其与COX-2表达的相关性

Expression of survivin in Gastrointestinal Stromal Tumors and Its Correlation With COX-2

目的探讨凋亡抑制蛋白survivin在胃肠道间质瘤(GISTs)组织中的表达情况及其与COX-2表达的相关性。方法采用免疫组化S-P法检测57例胃肠道间质瘤组织中survivn蛋白和COX-2蛋白的表达情况。结果57例GISTs中,survivin38例阳性,阳性率为66·7%;COX-2为47例阳性,阳性率82·5%。survivin的蛋白阳性表达率与GISTs的恶性潜能相关,差异有统计学意义(P<0·01);而COX-2蛋白的阳性表达率与GISTs的恶性潜能无关(P>0·05);survivin表达与COX-2表达呈正相关(P<0·01)。结论survivin在胃肠道间质瘤组织中表达升高,并与GISTs的恶性潜能相关,可成为预测GISTs恶性潜能的指标。survivin与GISTs组织中COX-2的阳性密切相关,两者可能存在共同的激活机制,参与抑制GISTs的细胞凋亡。

Objective To investigate the expression of inhibitor of apoptosis protein, survivin, in gastrointestinal stromal tumors （GISTs） and analyze its correlation with the expression of COX-2. Methods The expression of survivin and COX-2 were examined by using the streptavidin-biotin peroxidase（SP） method in 57 cases of GISTs. Results survivin was expressed in 38 of 57 （66. 7% ） cases of GISTs and COX-2 was expressed in 47 of 57 （82. 5 % ） cases of GISTs. The positive rates of survivin was associated with the malignant potential of GISTs（ P 〈0.01 ）. The positive rates of COX-2 was not associated with the malignant potential of GISTs（ P 〉 0. 05 ）. Survivin expression was positively related to COX-2 expression （ P 〈 0. 01 ）. Conclusion The expression of survivin increases in GISTs and is correlated with the malignant potential of GISTs, which suggests that it may be a predictor in evaluating the malignant potential of GISTs. A positive correlation between expressions of survivin and COX-2 is observed in GISTs. There may be a common transcription mechanism between them which plays an important role in suppressing tumor cell apoptosis in GISTs.