血清可溶性细胞间粘附分子-1评价冠心病慢性心力衰竭患者的临床价值

Clinical assessment in Patients with Chronic Congestive Heart Failure by serum concentration of sICAM-1

目的观察冠心病心力衰竭(CHF)患者血清可溶性细胞间粘附分子-1(sICAM-1)的变化。方法分别测定60例CHF患者血清sICAM-1水平比较,分析CHF患者与正常对照组(20例健康人)、不同心功能分级亚组之间上述指标的变化。结果CHF患者血清sICAM-1水平显著高于正常对照组(P<0.01),均随CHF程度加重而增高。不同心功能亚组之间血清sICAM-1水平有显著差异(P<0.05)。结论CHF患者血清sICAM-1显著增高,提示存在免疫激活和心肌炎性反应。血清sICAM-1水平的变化对于CHF病情程度、发展以及预后有一定的预测作用。

Objective To observe the serum concentration differences of soluble ICAM-1（sICAM-1） in patients with CHF.Methods Sixty patients with CHF have been choosed according to NYHA criteria of cardiac function,they were measured of the serum levels of ICAM-1.Twenty healthy people have been choosed as healthy control group,sICAM-1 has been measured.Results The concentrations of serum sICAM-1 in CHF patients are736.58±189.80μg/L,it is significently higher than those of the healthy control group 482.30±94.57μg/L（P〈0.01）;The worse of the cardiac function,the higher of the serum sICAM-1,especially the difference between cardiac function Ⅳ and Ⅱ,Ⅳ and Ⅲ,Ⅲ and Ⅱ（P〈0.01）.Conclusion The levels of serum sICAM-1 increase in CHF patients and are associated with the degree of CHF,the worse of the CHF function,the higher the sICAM-1.To measure the levels of serum sICAM-1 in CHF patients is helpful for evaluation the degree of heart failure.