Her-2,nm23,ER和PR在老年女性乳腺癌中的表达及意义

The significance of Her-2,nm23,ER and PR expression in elder breast cancer

目的研究老年女性乳腺癌中Her-2,nm23,ER和PR的表达及意义。方法用免疫组化法测定108例老年女性原发乳腺癌各抗体的表达情况。结果Her-2,nm23,ER和PR的阳性率分别为48.1%(52/108)、68.5%(74/108)、57.4%(62/108)和55.6%(60/108),Her-2随淋巴结转移数目的增多,其阳性表达率随之增加。ER阳性表达率随淋巴结转移数目的增多而降低。nm23的表达与淋巴结有无转移有关,转移组较无转移组阳性率明显下降,nm23的表达与临床分期相关有统计学意义。结论Her-2、ER、nm23与淋巴结转移有关,可以作为判断老年女性乳腺癌淋巴结转移和评估预后的有效指标。

Objective To investigate the expression and significance of Her-2,nm23,ER and PR in elder breast cancer.Method Immunohistochemical staining was used to detected the expression of Her-2,nm23,ER and PR in 108 cases of elder breast cancers.Results The expression of Her-2,nm23,ER and PR were observed in 48.1 %（52/108）,68.5%（74/108）,57.4%（62/108）,55.6%（60/108）of specimen respectively.The positive rate of Her-2 increased with the number of lymph node metastasis.The positive rate of ER decreased with the number of lymph node metastasis.The nm23 expression of group without lymph node metastasis（88.9%） was significantly higher than that of group lymph node metastasis（48.1%）.The difference between nm23 and clinicopathological stage was distinct.Conclusion Her-2,ER and nm23 were associated with the lymph node metastases,they may serve as useful markers to predict lymph node metastasis and to evaluate prognosis of elder women with breast cancer.