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ERCC2/XPD基因多态性与肺癌风险的研究进展 被引量:5

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摘要 切除修复交叉互补基因(ERCC2)/着色性干皮病基因(XPD)是一种重要的DNA损伤修复基因,参与DNA核苷酸切除修复。XPD基因几个核苷酸序列中存在多态性,其中312Asp/Asn和751Lys/Gln多态性比较常见。吸烟可引起人体细胞DNA损伤,90%以上的肺癌是由于主动吸烟或被动吸"二手"烟所致。本篇综述主要阐述XPD基因多态性及吸烟因素交互作用与肺癌风险的关系。
作者 李俊 毛伟敏
出处 《浙江实用医学》 2008年第2期143-146,共4页 Zhejiang Practical Medicine
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