摘要
目的:建立神脑舒胶囊中非法添加盐酸多塞平成分的鉴别方法。方法:采用色谱柱C18(250mm×2.0mm);乙腈-10mmol.L-1醋酸铵-三乙胺(65:35:0.5)(用醋酸调pH6.2)为流动相;流速:0.2mL.min-1;电喷雾离子化(ESI)scan方式;二级质谱母离子m/z280,碰撞能量15V。结果:在高效液相色谱、紫外光谱、质谱中,样品出现与盐酸多塞平成分一致的色谱峰、光谱图、质谱峰。结论:本方法简单可行,结果准确可靠,可用于神脑舒胶囊中添加盐酸多塞平成分的定性鉴别。
Objective:To establish a method to identify Doxepin Hydrochloride that mixed in Shennaoshu Capsules, Method:The separation was per- formed on a VP-ODS C18 (2.0 mm × 250 mm) analytical column, with the mixture of Aeetonitrile- 10 mol · L^ - 1 Ammonium acetate-Triethylamine(65:35 : 0, 5 ) (pH 6. 2) as the mobile phase at 0. 2 mL · min ^- 1 The ESI pattern was scan. Choose m/z 280 as precursor ion and set collision energy at 15V. Result :The same peaks as Doxepin Hydrochloride are found in Shennaoshu Capsules Condusion:The method is feasible, accurate, reliable and can be used for identifying Doxepin Hydroehloride mixed in Shennaoshu Capsules .
出处
《中国药品标准》
CAS
2008年第2期138-139,共2页
Drug Standards of China