腺苷脱氨酶和结核抗体检测在结核性胸腔积液诊断中的价值

Evaluation of the tests of ADA and anti-TB antibody in the diagnosis of tuberculous pleural effusion

目的评估腺苷脱氨酶(ADA)和结核抗体在结核性胸腔积液检测中的诊断意义。方法采用比色法和酶联免疫吸附试验(ELISA)对50患者结核性胸腔积液ADA和结核抗体水平进行了检测,并以45例恶性胸腔积液和30例右心功能不全引起的胸腔积液作对照。结果结核性胸腔积液ADA和结核抗体水平显著高于两对照组(P<0.01)。以ADA>45u/L作为阳性标准,其对结核性胸腔积液的敏感度为100%,特异度为98.6%,准确度为99.2%;结核抗体对结核性胸腔积液的敏感度为90%,特异度为93.3%,准确度为92%。结论ADA和结核抗体对诊断结核性胸腔积液均有重要价值。

Objective To evaluate the diagnostic values in the adenosine deaminase（ADA） and anti-TB antibody tests for tuberculous pleural effusion,Methods ADA and anti-TB antibody in pleural effusion were tested by colorimetric method and ELISA in 50 cases of tuberculous pleural effusion, 45 cases of malignant pleural effusion and 30 cases of right cardiac insufficiency pleural effusion, respectively. Results The levels of ADA and anti-TB antibody in pleural effusion were remarkably higher in tuberculous pleural effusion than in malignant pleural effusion and right cardiac insufficiency pleural effusion （P 〈 0.01）. When ADA 〉 45U/L and positive anti-TB antibody were present,their sensitivity, specificity and accuracy in diagnosis of tuberculous pleural effusion are 100%, 98.6%, 99.2% and 90% , 93,3%, 92%, respectively.Conclusion The tests of ADA and anti-TB antibody in pleural effusion are very important in diagnosis of tuberculous pleural effusion.